Human Lymphokine-Activated Killer Cells and Their Potential for Cancer Therapy
Data from numerous animal tumor models have led to the consensus that the cellular immune system contains the capacity to regulate autologous tumor growth. Differences exist with respect to the observed effector system(s) responsible for tumor regression: monocytes, helper T cells, killer T cells of varying and distinct phenotypes, cell populations expressing natural killer (NK) activity, and lymphokine-activated killer (LAK) cells each have been reported to be operative in the regulation of cancer. The recent development of DNA-produced immunological “hormones,” often called “cytokines,” has provided an unequaled opportunity to study basic aspects of immune regulation. In the USA, as well as in several other countries, the public has become increasingly aware of and interested in the potential therapeutic application of these cytokines, and hence they are already in the initial stages of testing for their value in cancer therapy.
KeywordsToxicity Oncol Sarcoma Stein Osteosarcoma
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