HMG-CoA to Isopentenyl Pyrophosphate — Enzymology and Inhibition

  • R. H. Abeles
Conference paper


Compactin (1, Fig. 1) and related compounds (Endo et al. 1976; Alberts et al. 1980) are powerful inhibitors (Ki ≈10−10M) of HMG-CoA reductase (Fig. 2). Examination of the structure of compactin does not suggest any obvious reasons why it should be an effective inhibitor of this enzyme.


Mevalonic Acid Isopentenyl Diphosphate Isopentenyl Pyrophosphate Dimethylallyl Diphosphate Nonsaponifiable Lipid 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • R. H. Abeles
    • 1
  1. 1.Graduate Department of BiochemistryBrandeis UniversityWalthamUSA

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