HMG-CoA to Isopentenyl Pyrophosphate — Enzymology and Inhibition

  • R. H. Abeles
Conference paper

Abstract

Compactin (1, Fig. 1) and related compounds (Endo et al. 1976; Alberts et al. 1980) are powerful inhibitors (Ki ≈10−10M) of HMG-CoA reductase (Fig. 2). Examination of the structure of compactin does not suggest any obvious reasons why it should be an effective inhibitor of this enzyme.

Keywords

Fluorine Lactone Allyl Diphosphate NADP 

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References

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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • R. H. Abeles
    • 1
  1. 1.Graduate Department of BiochemistryBrandeis UniversityWalthamUSA

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