Skip to main content

Regulation of the Depth of Anaesthesia: The Ultimate Goal of Quantitative Anaesthesia

  • Chapter
Quantitative Anaesthesia

Abstract

The control and/or regulation of the depth of anaesthesia is predicated on the existence of a measurable pharmacodynamic signal as a correlate of depth of anaesthesia, as well as on the existence of a quantitative description of the influence of anaesthetics on this correlate.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Arden JR, Holley FO, Stanski DR (1986) Increased sensitivity to etomidate in the elderly: initial distribution versus altered brain response. Anesthesiology 65:19

    Article  PubMed  CAS  Google Scholar 

  2. Asbury AJ (1985) Feedback control and model identification in the automatic control of neuromuscular blockade. In: Stoeckel H (ed) Quantitation, modelling and control in anaesthesia. Thieme, Stuttgart, p 274

    Google Scholar 

  3. Cosgrove RJ: Automatic, feedback controlled drug delivery devices. In: Smolen F, Bull LA (ed) Controlled drug bioavailability, vol 3. Wiley, New York, p 109

    Google Scholar 

  4. Fink M (1977) Quantitative EEG analysis and psychopharmacoloty. In: Remond A (ed) EEG informatics. A didactic review of methods and application of EEG data processing. Elsevier/North Holland, Amsterdam, p 301

    Google Scholar 

  5. Guedel, AE (1920) Third stage ether anesthesia: a subclassification regarding the significance of the position and movement of the eyeball. Am J Surg Anesth (Suppl) 34:53

    Google Scholar 

  6. Herrmann WM (1982) Development and critical evaluation of an objective procedure for the eleetroencephalographic classification of psychotropic drugs. In: Herrmann WM (ed) Electroencephaolography in drug research. Fischer, Stuttgart, p 249

    Google Scholar 

  7. Herrmann WM (ed) (1982) Electroencephalography in drug research. Fischer, Stuttgart

    Google Scholar 

  8. Hudson RJ, Stanski DR, Saidman LJ, Meathe E (1983) A model for studying depth of anesthesia and acute tolerance to thiopentone. Anesthesiology 59:301

    Article  PubMed  CAS  Google Scholar 

  9. Inoue M, Kajiya F, Inada H, Kitabatake A et al (1976) Optimal control of medical treatment: adaptive control of blood glucose level in diabetic coma. Comput Biomed Res 9:217

    Article  PubMed  CAS  Google Scholar 

  10. Lauven PM, Stoeckel H, Schwilden H (1985) Venous threshold concentrations of metho-hexitone (abstract). Anesthesiology 63 (Suppl):A368

    Article  Google Scholar 

  11. Low JM, Millard RK, Curnow JSH, Hutton P, Prys-Roberts C (1985) Servo-controlled infusion of sodium nitroprusside for induced hypotension. In: Stoeckel H (ed) Quantitation, modelling and control in anaesthesia. Thieme, Stuttgart, p 286

    Google Scholar 

  12. Prys-Roberts C (1987) Anaesthesia: a practical or impractical construct? Br J Anaesth 59:1341

    Article  PubMed  CAS  Google Scholar 

  13. Rampil IJ, Sasse FJ, Smith NT, Hoff BH, Fleming DC (1980) Spectral edge frequency — a new correlate of anesthetic depth. Anesthesiology 53:S12

    Article  Google Scholar 

  14. Schüttler J, Schwilden H, Stoeckel H (1985) Infusion strategies to investigate the pharmacokinetics and pharmacodynamics of hypnotic drugs: etomidate as an example. Eur J Anaesthesiol 2:133

    PubMed  Google Scholar 

  15. Schwilden H (1986) Die interaktive Dosierung intravenöser Anästhetika. Thieme, Stuttgart

    Google Scholar 

  16. Schwilden H, Stoeckel H (1980) Untersuchungen über verschiedene EEG-Parameter als Indikatoren des Narkosezustandes. Der Median als quantitatives Maß der Narkosetiefe. An-ästh Intensivther Notfallmed 15:279

    Article  CAS  Google Scholar 

  17. Schwilden H, Stoeckel H (1987) Quantitative EEG analysis during anaesthesia with isoflurane in nitrous oxide at 1.3 and 1.5 MAC. Br J Anaesth 59:738

    Article  PubMed  CAS  Google Scholar 

  18. Schwilden H, Schüttler J, Stoeckel H (1985) Quantitation of the EEG and pharmacodynamic modelling of hypnotic drugs: etomidate as an example. Eur J Anaesthesiol 2:121

    PubMed  CAS  Google Scholar 

  19. Schwilden H, Stoeckel H, Schüttler J, Lauven PM (1986) Pharmacological models and their use in clinical anaesthesia. Eur J Anaesthesiol 3:175

    PubMed  CAS  Google Scholar 

  20. Schwilden H, Schüttler J, Stoeckel H (1987) Closed-loop feedback control of methohexital anesthesia by quantitative EEG analysis in humans. Anesthesiology 67:341

    Article  PubMed  CAS  Google Scholar 

  21. Scott JC, Ponganis KV, Stanski DR (1985) EEG quantitation of narcotic effect: the comparative pharmacodynamics of fentanyl and alfentanil. Anesthesiology 62:234

    Article  PubMed  CAS  Google Scholar 

  22. Sheppart LC (1981) Computer control of the infusion of vasoactive drugs. Ann Biomed Eng 8:431

    Article  Google Scholar 

  23. Stoeckel H, Schwilden H (1984) Quantitative EEG-analysis and monitoring depth of anaesthesia. In: Gomez QJ, Egay LM, de la Cruz-Odi MF (eds) Anesthesia — safety for all. Elsevier, Amsterdam, p 151

    Google Scholar 

  24. Stoeckel H, Schwilden H (1986) Methoden der automatischen Feedback-Regelung für die Narkose. Konzepte und klinische Anwendung. Anästh Intensivmed Notfallmed 21:60

    Google Scholar 

  25. Vozeh S, Steimer J-L (1985) Feedback control methods for drug dosage optimisation. Concepts, classification and clinical application. Clin Pharmacokinet 10:457

    Article  PubMed  CAS  Google Scholar 

  26. Westenskow DR, Meline LJ, Pace NL, Bodily MN (1984) Sodium nitroprusside induced hypotension with computer adjustment for varying drug sensitivity. Anesth Analg 63:281

    Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Schwilden, H., Stoeckel, H., Schüttler, J. (1989). Regulation of the Depth of Anaesthesia: The Ultimate Goal of Quantitative Anaesthesia. In: van Ackern, K., Frankenberger, H., Konecny, E., Steinbereithner, K. (eds) Quantitative Anaesthesia. Anaesthesiologie und Intensivmedizin / Anaesthesiology and Intensive Care Medicine, vol 204. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74213-2_14

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-74213-2_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-50436-8

  • Online ISBN: 978-3-642-74213-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics