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Prostaglandins

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Pharmacology of Antihypertensive Therapeutics

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 93 / 1))

Abstract

Arachidonic acid (AA) is converted by different mammalian enzymes to a variety of prostaglandins, thromboxanes, prostacyclin, and leukotrienes. Products of the AA metabolic pathway contribute to the regulation of circulatory (cardiovascular) homeostasis as well as to the pathogenesis of several conditions, such as thrombotic disorders, Bartter’s syndrome, asthma, and inflammation. This review will focus on the impact of AA products on mechanisms of blood pressure regulation, such as renal function and vascular tone. The contribution of AA products to the pathogenesis of primary hypertension will be discussed.

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Authors
  1. G. Schröder
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  2. R. Gryglewski
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  3. J. Mehta
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  4. G. Stock
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Editor information

Editors and Affiliations

  1. German Institute for High Blood Pressure Research and Department of Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, D-6900, Heidelberg, Germany

    Detlev Ganten M.D, Ph.D.

  2. Medical College of Ohio, CS10008, 300 Arlington Avenue, Toledo, OH, 43699, USA

    Patrick J. Mulrow M.D.

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© 1990 Springer-Verlag Berlin Heidelberg

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Schröder, G., Gryglewski, R., Mehta, J., Stock, G. (1990). Prostaglandins. In: Ganten, D., Mulrow, P.J. (eds) Pharmacology of Antihypertensive Therapeutics. Handbook of Experimental Pharmacology, vol 93 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74209-5_12

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  • DOI: https://doi.org/10.1007/978-3-642-74209-5_12

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  • Print ISBN: 978-3-642-74211-8

  • Online ISBN: 978-3-642-74209-5

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