Release of lnterleukin-1 and Tumor Necrosis Factor by Rat Alveolar Macrophages after In Vivo or In Vitro Exposure to Mineral Dusts

  • K. E. Driscoll
  • R. C. Lindenschmidt
  • J. K. Maurer
  • J. M. Higgins
Part of the NATO ASI Series book series (volume 30)

Abstract

An important role in the pathogenesis of chronic fibrotic lung diseases has been ascribed to the alveolar macrophage (AM). This cell, depending on its state of activation, has the capacity to regulate various immunologic and inflammatory responses through the elaboration of biologically active cytokines. Two major macrophage-derived cytokines are interleukin-1 (IL-1) and tumor necrosis factor (TNF). IL-1, has been suggested as an AM-derived factor that is active in fibrogenic responses to mineral dusts (Schmidt et al., 1984). Since TNF, like IL-1, has pro-inflammatory activities, and recent reports indicate it can modulate fibroblast growth (Vilcek et al., 1986), it too may play a role in the development of pulmonary inflammation and fibrosis following mineral dust exposure.

Keywords

Titanium Dioxide Dust Albumin Syringe 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Estes JE, Pledger WJ, Gillespie GY (1984) Macrophage-derived growth factor for fibroblasts and interleukin-1 are distinct entities. J Leuk Biol 35: 115–129Google Scholar
  2. Libby P, Wyler DJ, Janicka MW, Dinarello CA (1984) Differential effects of human interleukin-1 on growth of human fibroblasts and vascular smooth muscle cells. Arteriosclerosis 5: 186–191Google Scholar
  3. Mizel SB (1984) Production and quantitation of lymphocyte activating factor (interleukin-1). In: Herscowitz, Holden, Bellanti, Ghaffar (eds) Manual of macrophage methodology. Marcel Dekker, New York, p 407Google Scholar
  4. Oghiso Y, Kubota Y (1986) Enhanced interleukin-1 production by alveolar macrophages and increases in la-positive lung cells in silica-exposed rats. Microbiol Immunol 30: 1189–1198PubMedGoogle Scholar
  5. Schmidt JA, Oliver CN, Lepe-Zuniga JL, Green I, Gery I (1984) Silica-stimulated monocytes release fibroblast proliferation factors identical ti interleukin-1. J Clin Invest 73: 1462–1472PubMedCrossRefGoogle Scholar
  6. Vilcek J, Palombella VT, Henriksen-DeStefano D, Swenson C, Feinman r, Hirai M, Tsujimoto M (1986) Fibroblast growth enhancing activity of tumor necrosis factor and its relationship to other polypeptide growth factors. J Exp Med 163: 632–643PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • K. E. Driscoll
    • 1
  • R. C. Lindenschmidt
    • 1
  • J. K. Maurer
    • 1
  • J. M. Higgins
    • 1
  1. 1.Human and Environmental Safety DivisionThe Procter & Gamble CompanyCincinnatiUSA

Personalised recommendations