Skip to main content
SpringerLink
Log in
Book cover

Receptors, Membrane Transport and Signal Transduction pp 95–101Cite as

Identification and Characterization of Adenylate Cyclases in Various Tissues by Monoclonal Antibodies

  • Conference paper

  • 194 Accesses

Part of the book series: NATO ASI Series ((ASIH,volume 29))

Abstract

In vertebrate cells, the adenylate cyclase is regulated by hormones or neurotransmitters. Adenylate cyclase of eucaryotic organisms is a membrane-bound multi-component enzyme. The complex contains hormone receptor (R), guanine nucleotide binding proteins (Gs and Gi.) and the catalytic unit (C). Recently the catalyst, a calmodulin-insensitive enzyme from myocardium and a calmodulin-sensitive enzyme from brain has been purified to homogeneity by forskolin-Sepharose affinity chromatography (Pfeuffer etal., 1985a; Pfeuffer etal. 1985b; Smi gel, 1986).

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Refernces

  • Brostrom, C.O., Huang, Y., Breckenridge, B.McL. and Wolff, D.J. (1975) Proc. Natl. Acad. Sci. USA 72, 64–68.

    Google Scholar 

  • Mollner, S. and Pfeuffer T. (1988) Eur. J. Biochem. 171, 265–271.

    Article  PubMed  CAS  Google Scholar 

  • Panchenko, M.P. and Tkachuck, V.A. (1984) FEBS Lett. 174, 50–54.

    Article  PubMed  CAS  Google Scholar 

  • Pfeuffer, E., Dreher, R.M., Metzger, H. and Pfeuffer, T. (1985a) Proc. Natl. Acad. Sci. USA 82, 3086–3090.

    Google Scholar 

  • Pfeuffer, E., Mollner, S. and Pfeuffer, T. (1985b) EMB0 J. 4, 3675–3679.

    CAS  Google Scholar 

  • Smigel, M.D. (1986) J. Biol. Chem. 261, 1975–1982.

    Google Scholar 

  • Sulimovici, S., Pinkus, L.M., Susser, F.I., and Roginsky, M.S. (1984) Arch, Biochem. Biophys. 234, 434–441.

    Article  CAS  Google Scholar 

  • Westcott, K.R. LaPorte, D.C., and Storm, D.R. (1979) Proc. Natl. Acad. Sci. USA 76, 204–208.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Physiological Chemistry, University of Würzburg, Koellikerstr. 2, D-8700, Würzburg, Federal Republic of Germany

    Stefan Mollner, Ulrich Heinz & Thomas Pfeuffer

Authors
  1. Stefan Mollner
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ulrich Heinz
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Thomas Pfeuffer
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Biological Research Center, The National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, 116 35, Athens, Greece

    A. E. Evangelopoulos

  2. Neurobiologie Moleculaire, Institut Pasteur, 28 Rue du Dr. Roux, 75724, Paris Cedex 15, France

    J. P. Changeux

  3. Membrane Bioenergetics Group, University of California, Berkeley, 2544 Life Sciences Building, 94720, Berkeley, CA, USA

    L. Packer

  4. Biological Research Center, The National Rellenic Research Foundation, 48 Vassileos Constantinou Avenue, 116 35, Athens, Greece

    T. G. Sotiroudis

  5. Centre for Biomembranes and Lipid Enzymology, State University of Utrecht, Padualaan 8, 3508 TB, Utrecht, The Netherlands

    K. W. A. Wirtz

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Mollner, S., Heinz, U., Pfeuffer, T. (1989). Identification and Characterization of Adenylate Cyclases in Various Tissues by Monoclonal Antibodies. In: Evangelopoulos, A.E., Changeux, J.P., Packer, L., Sotiroudis, T.G., Wirtz, K.W.A. (eds) Receptors, Membrane Transport and Signal Transduction. NATO ASI Series, vol 29. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74200-2_8

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-74200-2_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74202-6

  • Online ISBN: 978-3-642-74200-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation