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Phosphorylase Kinase and Protein Kinase C: Functional Similarities

  • T. G. Sotiroudis
  • S. M. Kyriakidis
  • L. G. Baltas
  • T. B. Ktenas
  • V. G. Zevgolis
  • A. E. Evangelopoulos
Conference paper
Part of the NATO ASI Series book series (volume 29)

Abstract

Protein serine and threonine Kinases can be classified into individual groups or subclasses on the basis of the type of regulation of their activities (Krebs, 1986). Two of the most intensively studied groups are Ca2+-regulated, i.e. the Ca2+/calmodulin (CaM)-dependent and the Ca2+-phospholipid (diacylglycerol)-dependent protein Kinases. Of the enzymes belonging in the category of Ca2+/ CaM-dependent Kinases, myosin light chain Kinases (MLCK) are distinguished by their high degree of substrate specificity and CaM dependency (Edelman et al, 1987). Fhosphorylase Kinase (FhK) another member of the same group is characterized by a broader substrate specificity. Its primary substrate is phosphorylase b but the enzyme may catalyze the phosphorylation of other proteins (Chan & Graves, 1984). In addition, a number of Ca2+/CaM-dependent multifunctional protein Kinases identified in a variety of tissues shows a broad substrate specificity suggesting that such a group of CaM-dependent protein Kinases may play inportant roles in the control of different cellular processes (Sienolikar etal, 1986). On the other hand, protein Kinase C (PKC) is a multifunctional protein Kinase identified by Nishizuka and co-worKers as a Ca2+- and phospholipid-dependent protein Kinase that plays a crucial role in the signal transduction for a variety of biologically active substances involved in cellular function and proliferation (Nishizuka, 1984).

Keywords

Phorbol Ester Myosin Light Chain Kinase Glycogen PhosPhorylase Dependent Protein Kinase Broad Substrate Specificity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • T. G. Sotiroudis
    • 1
  • S. M. Kyriakidis
    • 1
  • L. G. Baltas
    • 1
  • T. B. Ktenas
    • 1
  • V. G. Zevgolis
    • 1
  • A. E. Evangelopoulos
    • 1
  1. 1.The National Hellenic Research FoundationAthensGreece

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