Synergism Between Oncogenes in T-cell Lymphomagenesis

  • Anton Berns
  • Marco Breuer
  • Sjef Verbeek
  • Maarten van Lohuizen
Part of the NATO ASI Series book series (volume 34)


Insertional mutagenesis is one of the mechanisms by which retroviruses can transform cells. A number of proto-oncogenes have been shown to be activated by proviral insertion in retrovirally-induced tumors. Cloning of common proviral insertion sites has led to the discovery of a series of new (putative) oncogenes. Here we report on the involvement of pim-1. pim-2. c-myc. and N-myc in MuLV-induced T-cell lymphomas. Furthermore, we show that transgenic mice carrying an activated pim-1 gene are predisposed to lymphomagenesis and that these mice can be used to show cooperation between pim-1 and c-mvc or N-mvc in tumorigenesis.


Insertional Mutagenesis Mouse Mammary Tumor Virus Myeloid Tumor Tumorigenic Process Putative Oncogene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • Anton Berns
    • 1
    • 2
  • Marco Breuer
    • 1
    • 2
  • Sjef Verbeek
    • 1
    • 2
  • Maarten van Lohuizen
    • 1
    • 2
  1. 1.Division of Molecular GeneticsThe Netherlands Cancer InstituteAmsterdamThe Netherlands
  2. 2.The Department of Biochemistry of the University of AmsterdamAmsterdamThe Netherlands

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