Synergism Between Oncogenes in T-cell Lymphomagenesis

  • Anton Berns
  • Marco Breuer
  • Sjef Verbeek
  • Maarten van Lohuizen
Part of the NATO ASI Series book series (volume 34)


Insertional mutagenesis is one of the mechanisms by which retroviruses can transform cells. A number of proto-oncogenes have been shown to be activated by proviral insertion in retrovirally-induced tumors. Cloning of common proviral insertion sites has led to the discovery of a series of new (putative) oncogenes. Here we report on the involvement of pim-1. pim-2. c-myc. and N-myc in MuLV-induced T-cell lymphomas. Furthermore, we show that transgenic mice carrying an activated pim-1 gene are predisposed to lymphomagenesis and that these mice can be used to show cooperation between pim-1 and c-mvc or N-mvc in tumorigenesis.


Migration Lymphoma Leukemia Haas Thymoma 


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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • Anton Berns
    • 1
    • 2
  • Marco Breuer
    • 1
    • 2
  • Sjef Verbeek
    • 1
    • 2
  • Maarten van Lohuizen
    • 1
    • 2
  1. 1.Division of Molecular GeneticsThe Netherlands Cancer InstituteAmsterdamThe Netherlands
  2. 2.The Department of Biochemistry of the University of AmsterdamAmsterdamThe Netherlands

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