Dysregulated Activation of a Haemopoietic Growth Factor Gene Alone is Insufficient to Cause Malignant Haemopoietic Disease in Normal Haemopoietic Cells

  • J. M. Chang
  • G. R. Johnson
Part of the NATO ASI Series book series (volume 34)


Conceptually, autostimulation of haemopoietic cells is an attractive hypothesis for leukaemic transformation. Many reports based on experiments with haemopoietic growth factor dependent cell lines have documented that autonomous production of the growth factor causes the previously non-tumorigenic cell line to produce fatal tumours (Schräder and Crapper, 1983; Lang et al., 1985; Hapel et al., 1986; Laker et al., 1987; Wong et al., 1987). Whether such experiments have relevance to human leukaemia development, however, remains questionable. In the first instance, the murine cell lines used have acquired a number of genetic changes as is readily evident from their abnormal karyotype. Secondly, the development of these immortalised but haemopoietic growth factor dependent cell lines is readily achieved with murine cells but is an extremely rare event using human cells.


Bone Marrow Cell Acute Myeloblastic Leukaemia Haemopoietic Cell Nucleate Cell Count Irradiate Recipient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • J. M. Chang
    • 1
  • G. R. Johnson
    • 1
  1. 1.Cancer Research Unit The Walter and Eliza Hall Institute of Medical ResearchP.O. Royal Melbourne HospitalMelbourneAustralia

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