Abstract
The bone marrow is relatively accessible and contains cells which can reconstitute the entire haemopoietic system when transplanted into suitably conditioned hosts. In addition, methods are available for the manipulation of blood-forming cells in vitro. For these reasons haemopoietic cells are potential targets for therapeutic gene transfer. While this goal remains to be achieved, genes have already been successfully transferred to cultured cells for the study of normal and abnormal haemopoiesis (Spooncer et al., 1988). Despite these advances, however, much remains to be learned about the structure and function of the haemopoietic system. This paper reviews current understanding of haemopoietic regulation as it pertains to gene transfer strategies.
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© 1989 Springer-Verlag Berlin Heidelberg
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Daniel, C.P., Ponting, I.L.O., Hampson, J., Dexter, T.M. (1989). Haemopoietic Cells as Targets for Gene Transfer. In: Lother, H., Dernick, R., Ostertag, W. (eds) Vectors as Tools for the Study of Normal and Abnormal Growth and Differentiation. NATO ASI Series, vol 34. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74197-5_18
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DOI: https://doi.org/10.1007/978-3-642-74197-5_18
Publisher Name: Springer, Berlin, Heidelberg
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