Import of Preprocecropin A and Related Precursor Proteins into the Endoplasmic Reticulum
The cecropins are a family of potent antibacterial proteins that constitute a main part of the inducible cell-free immunity in insects (Boman and Hultmark, 1981, 1987). The secretory proteins cecropins A, B, and D from cecropia moth (Hyalophora cecropia) vary in size from 35 to 37 amino acid residues and are made as preproproteins with a size of 62 to 64 residues (Lidholm et al., 1987). Besides of the biological function of the mature forms, this protein family is interesting with respect to the processing steps involved in maturation of the prepro-forms to the biologically active proteins and with respect to the mechanism of import of the precursor proteins into the endoplasmic reticulum.
KeywordsMicrosomal Membrane Hybrid Protein Signal Recognition Particle Signal Peptidase Docking Protein
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