Signals and components involved in the translocation of proteins across the endoplasmic reticulum membrane
The endoplasmic reticulum (ER) is a major site of protein translocation in eukaryotic cells. Secretory proteins, lysosomal enzymes, lumenal proteins of the ER, plasma membrane proteins, integral ER membrane proteins, to name a few classes which have been studied extensively, are all translocated across or inserted into the ER membrane. Signals contained in the protein sequence target the protein to the ER and determine whether or not it is integrated in the membrane. The present review summarizes our current knowledge on some aspects of these problems, with special emphasis on the work carried out in our laboratory.
KeywordsSignal Sequence Endoplasmic Reticulum Membrane Protein Translocation Signal Recognition Particle Nascent Polypeptide Chain
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