Chromosomal Breakage in Response to Cross-linking Agents in the Diagnosis of Fanconi Anemia
The Fanconi anemia (FA) syndrome was originally described by Guido Fanconi in 1927. In his report he described three brothers with a condition resembling pernicious anemia. Evidently the anemia was the main symptom of the disease. Subsequently, other clinical symptoms (e.g., thumb aplasia and other skeletal abnormalities, café au lait spots, and growth retardation) frequently observed in FA have been described (Nilsson 1960; Fanconi 1967).
KeywordsAplastic Anemia Fanconi Anemia Lymphocyte Culture Xeroderma Pigmentosum Ataxia Telangiectasia
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