Chromosomal Breakage in Response to Cross-linking Agents in the Diagnosis of Fanconi Anemia
The Fanconi anemia (FA) syndrome was originally described by Guido Fanconi in 1927. In his report he described three brothers with a condition resembling pernicious anemia. Evidently the anemia was the main symptom of the disease. Subsequently, other clinical symptoms (e.g., thumb aplasia and other skeletal abnormalities, café au lait spots, and growth retardation) frequently observed in FA have been described (Nilsson 1960; Fanconi 1967).
KeywordsToxicity Platinum Anemia Penicillin Oncol
Unable to display preview. Download preview PDF.
- Fanconi G (1927) Familiäre infantile perniziosaartige Anämie (perniziöses Blutbild und Konstitution). Jahrb Kinderheilkd 117: 257–280Google Scholar
- German J, Caskie S, Schonberg S (1978) A simple cytogenetic test for increased mutagen-sensitivity. J Supramol Struct (Suppl) 2: 89Google Scholar
- Kwee ML, Poll EHA, Van de Kamp JJP, De Koning H, Eriksson AW, Joenje H (1983) Unusual response to bifunctional alkylating agents in a case of Fanconi anaemia. Hum Genet 64: 384–387Google Scholar
- Sasaki MS (1978) Fanconi’s anemia condition possibly associated with a defective DNA repair. In: Hanawalt PC, Friedberg EC, Cox CF (eds) DNA repair mechanisms. ICN-UCLA symposia on molecular and cellular biology, vol IX. Academic Press, New York San Francisco London, pp 675Google Scholar