Fanconi Anemia pp 137-144 | Cite as

Significance of Cellular Sensitivity in a Group of Parents of Fanconi Anemia Patients

  • M. P. Marx
  • S. Smith

Abstract

Since 1964, when Schroeder et al. reported an increased number of chromosomal and chromatid breaks in the lymphocyte cultures of patients with Fanconi anemia (FA), several methods for diagnosis and basic research, making use of various alkylating agents, cloning survival tests, induced sister chromatid exchanges (SCE), and 3H-thymidine uptake and incorporation have been described (Auerbach et al. 1981; Sasaki and Tonomura 1973; Cohen et al. 1982; Cervenka and Hirsch 1983; Shoyab et al. 1981; Wunder and Fleischer 1984; Berger et al. 1980). These tests facilitate a reliable differentiation between patients with FA and those with overlapping clinical features. However, a reliable method for the identification of FA heterozygotes is still hot available.

Keywords

Europe Anemia Glutamine Dition Mitomycin 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • M. P. Marx
  • S. Smith

There are no affiliations available

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