The Specific Interaction of Human Leukocyte Elastase with Various Protein Inhibitors
Human leukocyte elastase (HLE) is a major protein of the azurophilic granules of human polymorphonuclear granulocytes (Fig.1). It is believed to be normally involved in the intracellular degradation of cellular and phagocytosed proteins and bacteria. Upon stimulation it is, however, released into extracellular space: into the plasma, where it is normally blocked by the α1-proteinase inhibitor (α1PI), and into mucous secretions, where it can be inhibited by the mucous proteinase inhibitor (MPI).
KeywordsBinding Loop Methionine Sulfoxide Pancreatic Secretory Trypsin Inhibitor Porcine Pancreatic Elastase Specificity Pocket
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- Collins J, Blocker H, Maywald F, Ebbers J, Gross G, Meyerhans A, Schwellnus K, Böldicke T, Böcher M, Szardenings M, Frank R, Fritz H (1987) Febs Sattelite Meeting on Proteinase Inhibitors and Biological Control, Ljubljana/BRDO, July 4–7, 1987 (organized by H. Fritz and V. Turk)Google Scholar