The Specific Interaction of Human Leukocyte Elastase with Various Protein Inhibitors

Conference paper
Part of the Colloquium der Gesellschaft für Biologische Chemie 14.–16. April 1988 in Mosbach/Baden book series (MOSBACH, volume 39)

Abstract

Human leukocyte elastase (HLE) is a major protein of the azurophilic granules of human polymorphonuclear granulocytes (Fig.1). It is believed to be normally involved in the intracellular degradation of cellular and phagocytosed proteins and bacteria. Upon stimulation it is, however, released into extracellular space: into the plasma, where it is normally blocked by the α1-proteinase inhibitor (α1PI), and into mucous secretions, where it can be inhibited by the mucous proteinase inhibitor (MPI).

Keywords

Arginine Trypsin Methionine Leucine Val190 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bode W, Wei AZ, Huber R, Meyer E, Travis J, Neumann S (1986a) EMBO J 5:2453–2458PubMedGoogle Scholar
  2. Bode W, Papamokos E, Musil D, Seemüller V, Fritz H (1986b) EMBO J 5:813–818PubMedGoogle Scholar
  3. Bode W, Papamokos E, Musil D (1987) Eur J Biochem 166:673–692PubMedCrossRefGoogle Scholar
  4. Bode W, Engh R, Musil D, Thiele W, Huber R, Karshikov A, Brzin J, Kos J, Turk V (1988) EMBO J 7:2593–2599PubMedGoogle Scholar
  5. Collins J, Blocker H, Maywald F, Ebbers J, Gross G, Meyerhans A, Schwellnus K, Böldicke T, Böcher M, Szardenings M, Frank R, Fritz H (1987) Febs Sattelite Meeting on Proteinase Inhibitors and Biological Control, Ljubljana/BRDO, July 4–7, 1987 (organized by H. Fritz and V. Turk)Google Scholar
  6. Grütter MG, Fendrich G, Huber R, Bode W (1988) EMBO J 7:345–351PubMedGoogle Scholar
  7. Laskowski M Jr, Kato I (1980) Annu Rev Biochem 49:593–626PubMedCrossRefGoogle Scholar
  8. Laskowski M Jr, Kato I, Ardelt W, Cook J, Denton A, Empie MW, Kohr WJ, Park SJ, Parks K, Schatzley BL, Schoenberger OL, Tashiro M, Vichot G, Whatley HE, Wieczorek A, Wieczorek M (1987) Biochemistry 26:202–221PubMedCrossRefGoogle Scholar
  9. Löbermann H, Lottspeich F, Bode W, Huber R (1982) Hoppe-Seyler’s Z Physiol Chem 363: 1377–1388PubMedCrossRefGoogle Scholar
  10. Löbermann H, Tokuoka R, Deisenhofer J, Huber R (1984) J Mol Biol 177:531–556CrossRefGoogle Scholar
  11. Sinha S, Watorek W, Karr S, Giles J, Bode W, Travis J (1987) Proc Natl Acad Sci USA 82:2228–2232CrossRefGoogle Scholar
  12. Tschesche H, Beckmann J, Mehlich A, Schnabel E, Truscheit E, Wenzel H (1987) Biochim Biophys Acta 913:97–101PubMedCrossRefGoogle Scholar
  13. Wei AZ, Mayr I, Bode W (1988) FEBS Letters 234:367–373PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • W. Bode
    • 1
  1. 1.Max-Planck-Institut für BiochemieMartinsriedGermany

Personalised recommendations