The Specific Interaction of Human Leukocyte Elastase with Various Protein Inhibitors

Conference paper
Part of the Colloquium der Gesellschaft für Biologische Chemie 14.–16. April 1988 in Mosbach/Baden book series (MOSBACH, volume 39)


Human leukocyte elastase (HLE) is a major protein of the azurophilic granules of human polymorphonuclear granulocytes (Fig.1). It is believed to be normally involved in the intracellular degradation of cellular and phagocytosed proteins and bacteria. Upon stimulation it is, however, released into extracellular space: into the plasma, where it is normally blocked by the α1-proteinase inhibitor (α1PI), and into mucous secretions, where it can be inhibited by the mucous proteinase inhibitor (MPI).


Binding Loop Methionine Sulfoxide Pancreatic Secretory Trypsin Inhibitor Porcine Pancreatic Elastase Specificity Pocket 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • W. Bode
    • 1
  1. 1.Max-Planck-Institut für BiochemieMartinsriedGermany

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