Automated and High-Speed DNA Sequencing - Computer Technology Promotes Biological Advances
Forty years after the first electronic computer was developed, the use of this highly intelligent and versatile tool for studying molecular mechanisms of life has now become commonplace. Much of the impetus for the remarkable developments that have recently occurred, especially in the molecular aspect of biological science, is due to the vastly improved performance realized by the extensive application of computer and mechatronics to instrumentation science and technology. These developments are able to provide an extraordinary range of sensitivity, resolving power, dynamic range, and applicability, as well as to develop novel tools; only with the capability of present-day computers can complex structures and functions of living organisms be fully analyzed. In this chapter, I will show an aspect of the expanding applicability of modern technology including automation and robotics to the study of biological macromolecules with special reference to a large- scale DNA-base-sequencing system.
KeywordsBiological Macromolecule European Molecular Biology Laboratory Instrumentation Science Biological Advance Computer Technology Application
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