α-Bungarotoxin Receptor in a Human Neuroblastoma Cell Line

  • C. Gotti
  • E. Sher
  • D. Fornasari
  • B. Chini
  • A. Esparis Ogando
  • F. Clementi
Conference paper
Part of the NATO ASI Series book series (volume 25)

Abstract

The nicotinic acetylcholine receptor (AChR) is a neurotransmitter receptor which, upon acetylcholine binding, undergoes a conformational change, which triggers ion permeability by opening a self contained cation channel. AChr is present in muscle end plates, in ganglia and in the Central Nervous System (CNS), with different structural and functional characteristics. The most complete information on structure and function are available for AChR of skeletal muscles and fish electric organs (Conti-Tronconi and Raftery, 1982; Popot and Changeux, 1984). In the muscle receptor five subunits (α2, β, γ, δ) are arranged with pseudo-five-fold symmetry around the central cation conducting channel. Of the five subunits only the two a-subunits bind acetylcholine and cholinergic agents.

Keywords

Nicotine Retina Polypeptide Acetylcholine Neuroblastoma 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • C. Gotti
    • 1
  • E. Sher
    • 1
  • D. Fornasari
    • 1
  • B. Chini
    • 1
  • A. Esparis Ogando
    • 1
  • F. Clementi
    • 1
  1. 1.Department of Medical Pharmacology, CNR Center of CytopharmacologyUniversity of MilanMilanItaly

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