Developmental Regulation and Modulation of Neuronal Nicotinic Acetylcholine Receptor Channels
To date the best characterized receptor-channel complex is the muscle nicotinic acetylcholine receptor (AChR). Several studies demonstrate that muscle AChRs are subject to various forms of regulation. Distinct changes in channel properties, receptor distribution and subunit composition are observed over the course of development. Also, acute changes in the degree of receptor phosphorylation induce a functional change in the rate of receptor desensitization (for a review, see Schuetze and Role 1987). These extensive studies of muscle AChR regulation provide an important intellectual framework for studies of other ligand-gated channels in the central and peripheral nervous system.
KeywordsPolypeptide Norepinephrine Catecholamine HEPES Acetylcholine
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