Developmental Regulation and Modulation of Neuronal Nicotinic Acetylcholine Receptor Channels

  • Linda K. Simmons
  • Brenda L. Moss
  • Stephen M. Schuetze
  • Lorna W. Role
Conference paper
Part of the NATO ASI Series book series (volume 25)

Abstract

To date the best characterized receptor-channel complex is the muscle nicotinic acetylcholine receptor (AChR). Several studies demonstrate that muscle AChRs are subject to various forms of regulation. Distinct changes in channel properties, receptor distribution and subunit composition are observed over the course of development. Also, acute changes in the degree of receptor phosphorylation induce a functional change in the rate of receptor desensitization (for a review, see Schuetze and Role 1987). These extensive studies of muscle AChR regulation provide an important intellectual framework for studies of other ligand-gated channels in the central and peripheral nervous system.

Keywords

Polypeptide Norepinephrine Catecholamine HEPES Acetylcholine 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • Linda K. Simmons
    • 1
  • Brenda L. Moss
    • 1
    • 2
  • Stephen M. Schuetze
    • 1
  • Lorna W. Role
    • 1
  1. 1.Depts of Anatomy and Cell Biology in the Center for Neurobiology and BehaviorColumbia University College of Physicians of SurgeonsNYUSA
  2. 2.Dept of Biological SciencesColumbia UniversityNYUSA

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