Abstract
To date the best characterized receptor-channel complex is the muscle nicotinic acetylcholine receptor (AChR). Several studies demonstrate that muscle AChRs are subject to various forms of regulation. Distinct changes in channel properties, receptor distribution and subunit composition are observed over the course of development. Also, acute changes in the degree of receptor phosphorylation induce a functional change in the rate of receptor desensitization (for a review, see Schuetze and Role 1987). These extensive studies of muscle AChR regulation provide an important intellectual framework for studies of other ligand-gated channels in the central and peripheral nervous system.
The authors dedicate this chapter to the fond memory of their friend and colleague, Steve Schuetze.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Albuquerque, E., Deshpande, S., Aracava, Y., Alkondon, M. and Daly, J.W. (1986) A possible involvement of cyclic AMP in the expression of desensitization of the nicotinic acetylcholine receptor. A study with forskolin and its analogs. F.E.B.S. Lett. 199:113–120
Clapham, D. E. and Neher, E. (1984) Substance P reduces acetylcholine-induced currents in isolated bovine chromaffin cells. J. Physiol. 347: 255–277
Downing, J. D., Harish, O. H., and Role, L. W. (1987) Modulation of neuronal acetylcholine receptor desensitization by ganglionic peptides and agents that activate protein kinase C. Soc. Neurosci. Abs. 13: 704
Downing, J. D. and Role, L. W. (1987) Activators of protein kinase C enhance acetylcholine receptor desensitization in sympathetic ganglion neurons. PNAS 84: 7739–7743
Downing, J. D. and Role, L. W. Desensitization of the neuronal acetylcholine receptor: characterization and modulation by ganglionic peptides (In preparation)
Eusebi, F., Grassi, C, Nervi, C, Caparale, S., Adamo, B. and Molinaro, M. (1987) Acetylcholine may regulate its own nicotinic receptor-channel through the C-kinase system. Proc. Roy. Soc. Lond. B 230:355–365
Hamill, O. P., Marty, A., Neher, E., Sakmann, B. and Sigworth, F. J. (1981) Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Archiv 391, 85–100
Hayashi, M., Edgar, D. and Thoenen, H. (1983) The development of substance P, somatostatin and vasoactive intestinal polypeptide in sympathetic and spinal sensory ganglia of the chick embryo. Neurosci. 10:31–39
Huganir, R. L., Delcour, A. H., Greengard, P. and Hess, G. P. (1986) Phosphorylation of the nicotinic acetylcholine receptor regulates its rate of desensitization. Nature 321: 774–776
Margiotta, J. F. and Berg, D. K. (1986) Enkephalin and substance P modulate synaptic properties of chick ciliary ganglion neurons in cell culture. Neurosci. 18: 175–182
Middleton, P., Jaramillo, F. and Schuetze, S. M. (1986) Forskolin increases the rate of acetylcholine receptor desensitization at rat soleus endplates. PNAS 83: 4967–4971
New, H.V. and Mudge, A.W. (1986) Distribution and ontogony of SP, CGRP, SOM, and VIP in chick sensory and sympathetic ganglia. Dev. Biol. 116:337–346
Role, L. W. (1984) Substance P modulation of acetylcholine-induced currents in embryonic chicken sympathetic and ciliary ganglion neurons. PNAS 81: 2924–2928
Role, L. W. (1988) Neural regulation of acetylcholine sensitivity in embryonic sympathetic neurons. PNAS 85: 2925–2829
Sakmann, B., Patlak, J., and Neher, E. (1980) Single acetylcholine-activated channels show burst-kinetics in presence of desensitizing concentrations of agonist. Nature 286:71–73
Schuetzé, S. M. and Role, L. W. (1987) Developmental regulation of nicotinic acetylcholine receptors. Ann. Rev. Neuroci. 10: 403–457
Valenta, D. C. C, Downing, J. D. and Role, L. W. (1987) Peptidergic regulation of catecholamine secretion in embryonic sympathetic neurons. Soc. Neurosci. Abs. 13: 702
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Simmons, L.K., Moss, B.L., Schuetze, S.M., Role, L.W. (1988). Developmental Regulation and Modulation of Neuronal Nicotinic Acetylcholine Receptor Channels. In: Clementi, F., Gotti, C., Sher, E. (eds) Nicotinic Acetylcholine Receptors in the Nervous System. NATO ASI Series, vol 25. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74167-8_27
Download citation
DOI: https://doi.org/10.1007/978-3-642-74167-8_27
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-74169-2
Online ISBN: 978-3-642-74167-8
eBook Packages: Springer Book Archive