Pharmacology of a Locust Thoracic Ganglion Somal Nicotinic Acetylcholine Receptor
The dramatic increase in the number of highly-specific new receptor-binding drugs together with a flood of receptor amino acid sequences has revealed differences among receptor types hitherto thought to be virtually identical, as well as new relationships among apparently dissimilar receptor families. These new observations are forcing a re-evaluation of the old pharmacological classifications and raising interesting questions about the evolution and variation of receptor families in the different animal groups (Venter et al 1988). Our interest is in the receptors and ion channels of the insects and other arthropods, and how they compare pharmacologically and functionally with those of the vertebrates.
KeywordsNicotine Choline Acetylcholine Piperazinium Tetraethyl
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