Abstract
The effects of histamine, basic fibroblast growth factor (bFGF) and a melanocyte stimulating hormone (αMSH) on neurite outgrowth, proenkephalin A (pENK) and tyrosine hydroxylase (TH) gene expression have been studied in primary cultures of chromaffin cells from the adult bovine adrenal medulla. All three factors promote transdifferentiation to the neuronal phenotype (assessed by neurite outgrowth) but histamine acts with a much shorter latency than bFGF and αMSH. Moreover, only histamine produces any modification of pENK gene expression at the times examined (8,24,48 and 72h). Possible intracellular signalling mechanisms linked to transdifferentiation in bovine chromaffin cells are discussed.
on leave from Institut de Physiologie Général, UACNRS 309, Université Louis Pasteur, 67000 Strasbourg, France
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© 1989 Springer-Verlag Berlin Heidelberg
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Demeneix, B.A., Kley, N. (1989). Transdifferentiation to a Neuronal Phenotype in Adult Bovine Chromaffin Cells: Effects of αMSH, bFGF and Histamine. In: Maelicke, A. (eds) Molecular Biology of Neuroreceptors and Ion Channels. NATO ASI Series, vol 32. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74155-5_49
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DOI: https://doi.org/10.1007/978-3-642-74155-5_49
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