Advertisement

Cloning of a Rat D2-Dopamine Receptor cDNA

  • Olivier Civelli
  • James Bunzow
  • Hubert van Tol
  • David Grandy
  • Paul Albert
  • John Salon
  • Curtis Machida
  • Kim Neve
Conference paper
Part of the NATO ASI Series book series (volume 32)

Abstract

Recent structural analyses have revealed that neurotransmitter receptors can be divided into two families: the G protein-coupled receptors and the ligand-gated ion channels (Stevens, 1987; Dohlman, 1987; Hall, 1987).

Keywords

Cytoplasmic Loop Striatal Membrane Hydrophobic Stretch Spiperone Binding Guanine Nucleotide Regulatory Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Berridge MJ (1984) The molecular basis of communication within the cell. Sci Am 66: 142–152Google Scholar
  2. Boyson SJ, McGonigle P, Molinoff PB (1986) Quantitative autoradiographic localization of the D1 and D2 subtypes of dopamine receptors in rat brain. J of Neurosci 6: 3177–3188Google Scholar
  3. Cheng YC, Prusoff WH (1973) Relationship between the inhibition constant (Ki) and the concentration of inhibitor which causes 50 percent inhibition (I50) of an enzymatic reaction. Biochem Pharmacol 22: 3099–3108PubMedCrossRefGoogle Scholar
  4. Dixon RAF, Koblika BK, Strader DJ, Benovic JL, Dolhman HG, Frielle T, Bolanowski M, Bennett C, Rands E, Diehl R, Mumford R, Slater E, Sigal I, Caron M, Lefkowitz R, Strader C (1986) Cloning of the gene and cDNA for mammalian ß-adrenergic receptor and homology with rhodopsin. Nature 321: 75–79PubMedCrossRefGoogle Scholar
  5. Dohlman HG, Caron MG, Lefkowitz RJ (1987) A family of receptors coupled to guanine nucleotide regulatory proteins. Biochemistry 26: 2657–2664PubMedCrossRefGoogle Scholar
  6. Hall ZA (1987) Three of a kind: the ß-adrenergic receptor, the muscarinic acetylcholine receptor, and rhodopsin. Trends in Neuro Sci 10: 99–100CrossRefGoogle Scholar
  7. Julius D, MacDermott AB, Axel R, Jessell TM (1988) Molecular characterization of a functional cDNA encoding the serotonin lc receptor. 241: 558–564Google Scholar
  8. Masu Y, Nakayama K, Tamaki H, Harada Y, Kuno M, Nakanishi S (1987) cDNA cloning of bovine substance-K receptor through oocyte expression system. Nature 329: 836–838Google Scholar
  9. Noda M, Takahashi H, Tanabe T, Toyosato M, Furutani Y, Hirose T, Asai M, Inayama S, Miyata T, Numa S (1982) Primary structure of a subunit precursor of Torpedo californica acetylcholine receptor deduced from cDNA sequence. Nature 299: 793–797PubMedCrossRefGoogle Scholar
  10. Stevens CF (1987) Channel families in the brain. Nature 328: 198–199PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • Olivier Civelli
    • 1
  • James Bunzow
    • 1
  • Hubert van Tol
    • 1
  • David Grandy
    • 1
  • Paul Albert
    • 1
  • John Salon
    • 1
  • Curtis Machida
    • 1
  • Kim Neve
    • 1
  1. 1.Vollum Institute for Advanced Biomedical ResearchOregon Health Sciences UniversityPortlandUSA

Personalised recommendations