Common Structural Principles of Ion Channel Proteins
Hydropathy profiles of the available sequences of ion channel proteins (Fig. 1) suggest that ligand-gated and voltage-gated channels each form a structural family. Ligand-gated channel proteins consist of several subunits a combination of which must be inserted into the membrane to provide ligand-gated conductance (Mishina et al., 1984). In contrast, functional voltage-gated sodium channels are already obtained when only the large subunit is expressed (Noda et al., 1986).
KeywordsAcetylcholine Receptor Nicotinic Acetylcholine Receptor Gaba Receptor Glycine Receptor Putative Transmembrane Domain
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