Common Structural Principles of Ion Channel Proteins

  • Alfred Maelicke
Conference paper
Part of the NATO ASI Series book series (volume 32)

Abstract

Hydropathy profiles of the available sequences of ion channel proteins (Fig. 1) suggest that ligand-gated and voltage-gated channels each form a structural family. Ligand-gated channel proteins consist of several subunits a combination of which must be inserted into the membrane to provide ligand-gated conductance (Mishina et al., 1984). In contrast, functional voltage-gated sodium channels are already obtained when only the large subunit is expressed (Noda et al., 1986).

Keywords

Glycine Cysteine Acid Number Polypeptide Choline 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • Alfred Maelicke
    • 1
  1. 1.Max-Planck-Institut für ErnährungsphysiologieDortmund 1Germany

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