Membrane Currents of Retinal Bipolar Cells: Goldfish vs. Mouse
The time course of light-evoked responses differs greatly between neurons of the distal retina and the proximal retina. In the distal retina, photoreceptors, horizontal cells and bipolar cells show sustained light responses, while in the proximal retina responses of amacrine and ganglion cells have prominent transient components even in those cells classified as a sustained type. Shaping of signals from sustained to transient may involve various mechanisms; activation of specific membrane conductances of amacrine and ganglion cells, interaction between excitatory and inhibitory signals that arrive to a postsynaptic cell with time delay, or a transient release of transmitter substance from presynaptic (bipolar) cells.
KeywordsRetina Nifedipine Papain Dihydropyridine
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- Balkema GW, Mangini NJ, Pinto LH, Vanable JW Jr (1984) Visually evoked eye movements in mouse mutants and inbred strains. Invest Ophthalmol Visual Sci 25: 795–800Google Scholar
- Baylor DA, Nunn BJ, Schnapf JL (1984) The photocurrent, noise and spectral sensitivity of rods of the monkey Macaca fascilularis. J Physiol (Lond) 357: 575–607Google Scholar
- Hagiwara N, Irisawa H, Kameyama M (1988) Contribution of two types of calcium currents to the pacemaker potentials of rabbit sino-atrial node cells. J Physiol (Lond) 395: 233–253Google Scholar
- Kaneko A, Pinto LH, Tachibana M (1989) Transient calcium current of retinal bipolar cells of the mouse. J Physiol (Lond) (in press)Google Scholar
- Kaneko A, Tachibana M (1985) A voltage-clamp analysis of membrane currents in solitary bipolar cells dissociated from Carassius auratus. J Physiol (Lond) 358: 131–152Google Scholar
- Nilius B, Hess P, Lansman JB, Tsien RW (1985) A novel type of cardiac calcium channel in ventricular cells. Nature 291: 497–500Google Scholar