Integration of Synaptic Input from On and Off Pathways in Mudpuppy Retinal Ganglion Cells

  • John S. McReynolds
  • Peter D. Lukasiewicz
Part of the NATO ASI Series book series (volume 31)


Based on their responses to steady illumination of the receptive field center, retinal ganglion cells in cold-blooded vertebrates are often classified into three main types, On-center, Off-center and On-Off, which in some cases may be further sub-divided according to other criteria such as directional selectivity. In mudpuppy and tiger salamander, electrophysiological studies have revealed that each type of ganglion cell can receive several physiologically different types of synaptic input (for example, sustained and transient excitation, and sustained and transient inhibition) which are integrated to produce complex responses. This article will first summarize briefly the different types of synaptic inputs to ganglion cells in mudpuppy and tiger salamander, and then concentrate on the convergence of inputs from the On and Off pathways.


Ganglion Cell Synaptic Input Bipolar Cell Amacrine Cell Inhibitory Input 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • John S. McReynolds
    • 1
  • Peter D. Lukasiewicz
    • 1
  1. 1.Department of PhysiologyThe University of MichiganAnn ArborUSA

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