Integration of Synaptic Input from On and Off Pathways in Mudpuppy Retinal Ganglion Cells

  • John S. McReynolds
  • Peter D. Lukasiewicz
Part of the NATO ASI Series book series (volume 31)

Abstract

Based on their responses to steady illumination of the receptive field center, retinal ganglion cells in cold-blooded vertebrates are often classified into three main types, On-center, Off-center and On-Off, which in some cases may be further sub-divided according to other criteria such as directional selectivity. In mudpuppy and tiger salamander, electrophysiological studies have revealed that each type of ganglion cell can receive several physiologically different types of synaptic input (for example, sustained and transient excitation, and sustained and transient inhibition) which are integrated to produce complex responses. This article will first summarize briefly the different types of synaptic inputs to ganglion cells in mudpuppy and tiger salamander, and then concentrate on the convergence of inputs from the On and Off pathways.

Keywords

Glycine Retina Choline Acetyl Strychnine 

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References

  1. Arkin MS, Miller RF (1988) Bipolar origin of synaptic inputs to sustained Off ganglion cells in the mudpuppy retina. J Neurophysiol (in press)Google Scholar
  2. Beigum JH, Dvorak DR, McReynolds JS (1982) Sustained synaptic input to ganglion cells of mudpuppy retina. J Physiol 326: 91–108Google Scholar
  3. Beigum JH, Dvorak DR, McReynolds JS (1983) Sustained and transient inhibitory inputs to on-off ganglion cells in the mud-puppy retina. J Physiol 340: 599–610Google Scholar
  4. Beigum JH, Dvorak DR, McReynolds JS (1984) Strychnine blocks transient but not sustained inhibition in mudpuppy retinal ganglion cells. J Physiol 354: 273–286Google Scholar
  5. Beigum JH, Dvorak DR, McReynolds JS, Miyachi E-I (1987) Push- pull effect of surround illumination on excitatory and in-hibitory inputs to mudpuppy retinal ganglion cells. J Physiol 388: 233–243Google Scholar
  6. Dacheux RF, Frumkes TE, Miller RF (1979) Pathways and polarities of synaptic interactions in the inner retina of the mudpuppy. I. Synaptic blocking studies. Brain Res 161: 1–12Google Scholar
  7. Dong C-J, McReynolds JS (1988) APB increases electrical coupling between horizontal cells in mudpuppy retina. Vision Res (in press)Google Scholar
  8. Frumkes TE, Miller RF, Slaughter M, Dacheux RF (1981) Physiological and pharmacological basis of GABA and glycine action on neurons of mudpuppy retina. III. Amacrine-mediated inhibitory influences on ganglion cell receptive-field organization: a model. J Neurophysiol 45: 783–804.PubMedGoogle Scholar
  9. Kujiraoka T, Saito T, Toyoda J-I (1986) Bipolar-amacrine synaptic transmission: effect of polarization of bipolar cells on amacrine cells in carp retina. Neuroscience Res 4 (suppl): 111–119CrossRefGoogle Scholar
  10. Lukasiewicz PD, McReynolds JS (1985) Synaptic transmission at N-methyl-D-aspartate receptors in the proximal retina of the mudpuppy. J Physiol 367: 99–115PubMedGoogle Scholar
  11. Maguire G, Lukasiewicz P, Werblin F (1988) Neural interactions underlying the response to change in the tiger salamander retina. J Neuroscience (in press)Google Scholar
  12. Marchiafava PL, Torre V (1978) The responses of amacrine cells to light and intracellularly applied currents. J Physiol 276: 83–102PubMedGoogle Scholar
  13. Masland RH, Mills JW, Cassidy C (1984) The functions of acetyl-choline in the rabbit retina. Proc R Soc Lond B 223: 121–139PubMedCrossRefGoogle Scholar
  14. Massey SC, Redburn DA, Crawford MLJ (1983) The effects of 2- amino-4-phosphono-butyric acid ( APB) on the ERG and ganglion cell discharge of rabbit retina. Vision Res 23: 1607–1613Google Scholar
  15. McGuire BA, Stevens JK, Sterling P (1986) Microcircuitry of beta ganglion cells in cat retina. J Neuroscience 6: 907–918Google Scholar
  16. McReynolds JS, Miyachi E-I (1986) The effect of cholinergic agonists and antagonists on ganglion cells in the mudpuppy retina. Neuroscience Res 4 (suppl): 153–161CrossRefGoogle Scholar
  17. Powers M, DeMarco P, Bilotta J (1988) APB eliminates ERG b-wave but not optic nerve “ON” response in goldfish. Invest Ophthalmol Vis Sci 29 (suppl): 104Google Scholar
  18. Slaughter MM, Miller RF (1981) 2-Amino-4-phosphonobutyric acid: a new pharmacological tool for retina research. Science 211: 182–185Google Scholar
  19. Slaughter MM, Miller RF (1983) Bipolar cells in the mudpuppy retina use an excitatory amino acid neurotransmitter. Nature 303: 537–538PubMedCrossRefGoogle Scholar
  20. Toyoda J-If Fujimoto M (1984) Application of transretinal current stimulation for the study of bipolar-amacrine transmission. J Gen Physiol 84: 915–925CrossRefGoogle Scholar
  21. Wässle H, Schaefer-Trenkler I, Voigt T (1986) Analysis of a glycinergic inhibitory pathway in the cat retina. J Neuros-cience 6: 594–604Google Scholar
  22. Werblin FS (1972) Lateral interactions at inner plexiform layer of a vertebrate retina: antagonistic response to change. Science 175: 1008–1010PubMedCrossRefGoogle Scholar
  23. Werblin FS, Copenhagen DR (1974) Control of retinal sensitivity. III. Lateral interactions at the inner plexiform layer. J Gen Physiol 63: 88–110Google Scholar
  24. Werblin FS, Dowling JE (1969) Organization of the retina of the mudpuppy, Necturus maculosus. II. Intracellular recording. J Neurophysiol 32: 331–355Google Scholar
  25. Werblin FS, Maguire G, Lukasiewicz P, Eliasof S, Wu S (1988) Neural interactions mediating the detection of motion in the retina of the tiger salamander. Visual Neuroscience (in press)Google Scholar
  26. Wunk DF, Werblin FS (1979) Synaptic inputs to the ganglion cells in the tiger salamander retina. J Gen Physiol 73: 265–286PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • John S. McReynolds
    • 1
  • Peter D. Lukasiewicz
    • 1
  1. 1.Department of PhysiologyThe University of MichiganAnn ArborUSA

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