Estimation of the Aqueous Solubility of Organic Compounds

  • S. H. Yalkowsky
Conference paper


In spite of its importance to a number of scientific disciplines, there are few reliable techniques for the estimation of the aqueous solubility of a crystalline organic compound. One of the major reasons for the lack of progress in this field is the fact that solubility is not strictly an additive, constituative property, and thus cannot be predicted by group contributions alone.


Salicylic Acid Acetylsalicylic Acid Aqueous Solubility Fumaric Acid Rigid Molecule 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • S. H. Yalkowsky
    • 1
  1. 1.College of PharmacyUniversity of ArizonaTucsonUSA

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