Methyl Parathion Toxicity in Rats is Changed by Pretreatment with the Pesticides Chlordecone, Mirex and Linuron

  • K. G. Tvede
  • S. Loft
  • H. E. Poulsen
  • J. S. Schou
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 13)

Abstract

Methyl parathion administration (MPT) leads to a dose-dependent reduction of acetylcholinesterase activity (Benke and Murphy 1975). The mechanism of action requires activation of methyl paraoxone by the hepatic enzyme system, presumably by cytochrome P-450-mediated metabolism. Phenobarbital, the P-450 inducer, can reduce the toxicity of MPT (Sultatos 1987), whereas some pesticides may change the hepatic enzyme system. The purpose of the present investigation was to elucidate if pretreatment with other pesticides and phenobarbital changed the toxicity of MPT, expressed by the AChE activity in the brain, after a sublethal dose of the organophosphate.

Abbreviations

MPT

Methyl parathion

AChE

acetylcholinesterase

PB

phenobarbital

References

  1. Benke GM, Murphy SD (1975) The influence of age on the toxicity and metabolism of methyl parathion and parathion in male and female rats. Toxicology Appl Pharmacol 31: 254–269CrossRefGoogle Scholar
  2. Ellman GL, Courtney KD, Andres V, Featherstone RM (1961) A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 7: 88–95PubMedCrossRefGoogle Scholar
  3. Sultatos LG (1987) The role of the liver in mediating the acute toxicity of the pesticide methyl parathion in mice. Drug Metabolism Dispos 15: 613–617Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • K. G. Tvede
    • 1
  • S. Loft
    • 1
  • H. E. Poulsen
    • 1
  • J. S. Schou
    • 1
  1. 1.Department of PharmacologyUniversity of CopenhagenCopenhagen ØDenmark

Personalised recommendations