Methyl Parathion Toxicity in Rats is Changed by Pretreatment with the Pesticides Chlordecone, Mirex and Linuron
Methyl parathion administration (MPT) leads to a dose-dependent reduction of acetylcholinesterase activity (Benke and Murphy 1975). The mechanism of action requires activation of methyl paraoxone by the hepatic enzyme system, presumably by cytochrome P-450-mediated metabolism. Phenobarbital, the P-450 inducer, can reduce the toxicity of MPT (Sultatos 1987), whereas some pesticides may change the hepatic enzyme system. The purpose of the present investigation was to elucidate if pretreatment with other pesticides and phenobarbital changed the toxicity of MPT, expressed by the AChE activity in the brain, after a sublethal dose of the organophosphate.
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