Effect of Netilmicin and Amikacin on Urinary Phospholipids Excretion in Humans
Lysosomal phospholipidosis of proximal tubular cells is an early index of aminoglycoside-induced nephrotoxicity and has been documented both biochemically and morphometrically in animals and humans treated with therapeutic doses of these antibiotics (see Laurent and Tulkens 1987, for review). The various aminoglycosides differ in their capacity to induce this alteration (Laurent et al 1982; De Broe et al 1984) and amikacin, in particular, induces considerably less changes than netilmicin (Tulkens et al 1983; De Broe et al 1983). In animals, aminoglycoside administration is also associated with a marked increase of phospholipiduria (Ibrahim and Tulkens 1986; Josepovitz et al 1986). The purpose of present study was to examine phospholipiduria in humans and to compare the effect of amikacin and netilmicin in this respect.
KeywordsPhosphorus Creatinine Chloroform Iodine Glycoside
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