Effect of Netilmicin and Amikacin on Urinary Phospholipids Excretion in Humans

  • S. Ibrahim
  • P. Van der Auwera
  • F. Meunier
  • P. M. Tulkens
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 13)

Abstract

Lysosomal phospholipidosis of proximal tubular cells is an early index of aminoglycoside-induced nephrotoxicity and has been documented both biochemically and morphometrically in animals and humans treated with therapeutic doses of these antibiotics (see Laurent and Tulkens 1987, for review). The various aminoglycosides differ in their capacity to induce this alteration (Laurent et al 1982; De Broe et al 1984) and amikacin, in particular, induces considerably less changes than netilmicin (Tulkens et al 1983; De Broe et al 1983). In animals, aminoglycoside administration is also associated with a marked increase of phospholipiduria (Ibrahim and Tulkens 1986; Josepovitz et al 1986). The purpose of present study was to examine phospholipiduria in humans and to compare the effect of amikacin and netilmicin in this respect.

Keywords

Phosphorus Creatinine Chloroform Iodine Glycoside 

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References

  1. Bartlett GR (1959) Phosphorus assay in column chromatography. J Biol Chem 234: 466–468PubMedGoogle Scholar
  2. De Broe ME, Paulus GJ, Verpooten GA, Giuliano RA, Roels F, Tulkens PM (1983) Early toxicity of aminoglycosides in human kidney: a prospective, comparative study of amikacin, gentamicin, netilmicin and tobramycin. In Proceedings of the 13th International Congress of Chemotherapy, Vienna vol 86. Spitzy KH & Karrer K (ed) 86/11–24Google Scholar
  3. De Broe ME, Paulus GJ, Verpooten G A, Roels F, Buyssens N, Wedeen R, Tulkens PM (1984) Early effects of gentamicin, tobramycin and amikacin on the human kidney. Kidney Int 25: 643–652PubMedCrossRefGoogle Scholar
  4. Giuliano RA, Paulus GJ, Verpooten RA, Pattyn V, Pollet DE, Tulkens PM, De Broe ME (1984) Recovery of cortical phospholipidosis and necrosis after acute gentamicin loading in rats. Kidney Int 26: 838–847PubMedCrossRefGoogle Scholar
  5. Ibrahim S, Carlier MB, Laurent G, Tulkens PM (1985) Quantitative analysis of the phospholipid composition of rat kidney cortex after treatment with gentamicin, dibekacin, netilmicin and tobramycin at low doses (10 mg/kg). In 25th Intersc Conf Antimicrob Agents Chemother, Minneapolis, Minn Abstract no. 708Google Scholar
  6. Ibrahim S, Tulkens PM (1986) Increased urinary excretion and change of patterns of phospholipds in gentamicin treated rats. In 26th Intersc Conf Antimicrob Agents Chemother, New Orleans, La Abstract no. 27Google Scholar
  7. Josepovitz C, Farruggella T, Levine R, Lane B, Kaloyanides GJ (1985) Effect of netilmicin on the phospholipid composition of subcellular fractions of rat renal cortex. J Pharmacol Exp Ther 235: 810–819PubMedGoogle Scholar
  8. Josepovitz C, Levine R, Farruggella T, Kaloyanides GJ (1986) Comparative effects of aminoglycosides on renal cortical and urinary phospholipids in the rat. Proc Soc Exp Biol Med 182: 1–5PubMedGoogle Scholar
  9. Kosek JC, Mazze RI, Cousins MJ (1984) Nephrotoxicity of gentamicin. Lab Invest 30: 48–57Google Scholar
  10. Laurent G, Carlier MB, Rollmann B, Van Hoof F, Tulkens P (1982) Mechanism of aminoglycoside-induced lysosomal phospholipidosis : in vitro and in vivo studies with gentamicin and amikacin. Biochem Pharmacol 31: 3861–3870PubMedCrossRefGoogle Scholar
  11. Laurent G, Tulkens PM (1987) Aminoglycoside nephrotoxicity: cellular and molecular espects. ISI Atlas of Science/Pharmacology vol 1: 40–44Google Scholar
  12. Tulkens P, Laurent G, Carlier MB, Toubeau G, Heuson-Stiennon J, Maldague P (1983) Comparative study of the alterations induced in rat kidney by gentamicin, dibekacin, netilmicin, tobramycin and amikacin at low doses. In Proceedings of the 13th International Congress of Chemotherapy, Vienna vol 86. Spitzy KH & Karrer K (ed) 86/30–35.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • S. Ibrahim
    • 1
  • P. Van der Auwera
    • 2
  • F. Meunier
    • 2
  • P. M. Tulkens
    • 1
  1. 1.Laboratoire de Chimie Physiologique & International Institute of Cellular and Molecular PathologyUniversité Catholique de LouvainBelgium
  2. 2.Institut Jules BordetUniversité Libre de BruxellesBruxellesBelgium

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