Influence of Triethylenetetramine and D-Penicillamine on Zinc Metabolism in Mice
Triethylenetetramine (TETA) is a copper chelator used in the treatment of Wilson’s disease. It is applied primarily to patients with adverse reactions to D-penicillamine (DPA) (Walshe 1973). DPA influences the metabolism of the essential trace element zinc (Klingberg et al 1976). Several adverse effects including teratogenicity may be caused by the zinc depletion. It was also suggested that the teratogenicity of TETA may be due at least partly through induction of zinc toxicity (Keen et al 1983). However, the affinity of TETA for zinc in vivo was not systematicaly investigated.
KeywordsBody Burden Zinc Metabolism Peroral Administration Zinc Depletion Total Body Burden
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