Influence of Triethylenetetramine and D-Penicillamine on Zinc Metabolism in Mice

  • V. Eybl
  • M. Koutenská
  • J. Koutenský
  • J. Sýkora
  • V. Smolíková
Conference paper
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 13)

Abstract

Triethylenetetramine (TETA) is a copper chelator used in the treatment of Wilson’s disease. It is applied primarily to patients with adverse reactions to D-penicillamine (DPA) (Walshe 1973). DPA influences the metabolism of the essential trace element zinc (Klingberg et al 1976). Several adverse effects including teratogenicity may be caused by the zinc depletion. It was also suggested that the teratogenicity of TETA may be due at least partly through induction of zinc toxicity (Keen et al 1983). However, the affinity of TETA for zinc in vivo was not systematicaly investigated.

Keywords

Zinc Toxicity Lamine Dihydrochloride Triethylene 

Abbreviations

DPA

D-Penicillamine

TETA

Triethylenetetraming

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Eybl Y, Sykora J, Mertl F (1970) Einfluß der Ca-Komplexe der Aminopolykarbonsäuren auf die Ausscheidung und die Verteilung des Zinks. Z ges exp Med 152: 274–183CrossRefGoogle Scholar
  2. Keen CL, Cohen NL, Lönnerdal BO, Hurley LS (1983) Teratogenesis and low copper status resulting from triethylenetetramine in rats. Proc Soc Exp Biol Med 173: 598–605PubMedGoogle Scholar
  3. Klingberg WG, Prasad AS, Oberleas D (1976) Zinc deficiency following penicillamine therapy. In: Prasad AS (ed): Trace elements in humans health and disease. I Zinc and copper. New York, Academic Press, pp 51–65Google Scholar
  4. Walshe JM (1973) Copper chelation in patients with Wilson’s disease. A comparison of penicillamine and triethylene tetramine dihydrochloride. J Med 167: 441–452Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • V. Eybl
    • 1
  • M. Koutenská
    • 1
  • J. Koutenský
    • 1
  • J. Sýkora
    • 1
  • V. Smolíková
    • 2
  1. 1.Department of PharmacologyCharles UniversityPilsenCSSR
  2. 2.Central Radioisotope Laboratory, Faculty of MedicineCharles UniversityPilsenCSSR

Personalised recommendations