Advertisement

Different Effects of Intraperitoneally and Orally Administered Palladium Chloride on the Hepatic Monooxygenase System of Male Mice

  • T. Phielepeit
  • W. Legrum
  • K. J. Netter
  • W. T. Klötzer
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 13)

Abstract

Palladium (Pd) has recently attracted increased attention amongst toxicologists, since it is the main constituent of standard dental alloys and an essential part in automobile catalytic exhaust converters.

Keywords

Microsomal Protein Hepatic Cytochrome Palladium Chloride Hepatic Content Distinct Biological Effect 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Aitio A (1978) A simple and sensitive assay of 7-ethoxycoumarin deethylation. Anal Biochem 85: 488–491PubMedCrossRefGoogle Scholar
  2. Goyer RA (1983) Metal-protein complexes in detoxification processes. In: Brown SS and Savory J (eds) Academic Press, New York (Chemical toxicology and clinical chemistry of metals, pp 199–209)Google Scholar
  3. Holbrook DJ, Washington ME, Leake HB, Brubaker PE (1976) Effects of platinum and palladium salts on parameters of drug metabolism in rat liver. J Toxicol Environm Hlth 1: 1067–1079CrossRefGoogle Scholar
  4. Jeffery EH, Jansen HT, Dellinger DA (1987) In vivo interactions of aluminum with hepatic cytochrome P450 and metallothionein. Fundam Appl Toxicol 8: 541–548PubMedCrossRefGoogle Scholar
  5. Lorke D (1983) A new approach to practical acute toxicity testing. Arch Toxicol 54: 275–287PubMedCrossRefGoogle Scholar
  6. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265–275PubMedGoogle Scholar
  7. Netter KJ (1960) Eine Methode zur direkten Messung der O-Demethylierung in Lebermikrosomen und ihre Anwendung auf die Mikrosomenhemmwirkung von SKF 525-A. Naunyn-Schmiedebergs Arch exp Path Pharmak 238: 292–300Google Scholar
  8. Nielson KB, Atkin CL, Winge DR (1985) Distinct metal-binding configurations in metallothionein. J Biol Chem 260: 5342–5350PubMedGoogle Scholar
  9. Omura T, Sato R (1964) The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature. J Biol Chem 239: 2370–2378PubMedGoogle Scholar
  10. Perkin-Elmer (1980) Norwalk, USA (Manual: atomic absorption spectrometer, model 5000)Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • T. Phielepeit
    • 1
  • W. Legrum
    • 1
  • K. J. Netter
    • 1
  • W. T. Klötzer
    • 2
  1. 1.Department of Pharmacology and ToxicologyLahnbergeGermany
  2. 2.Department of Prosthetic DentistryGeorg-Voigt-Strasse, Philipps-University of MarburgMarburgGermany

Personalised recommendations