Depletion of Hepatic Glutathione in Rats Impairs Phagocytosis In Vivo
Glutathione is involved in the protection of phagocytes against oxidative damage and in the assembly and preservation of microtubules during phagocytosis (Voetmann et al 1980). The phagocytotic activity may be impaired by depletion of GSH in phagocytes. This may lead to a failure of unspecific and specific defense mechanisms, such as the clearance of microparticles from blood by Kupffer cells (Altura 1980), which are resident macrophages in the liver. In the present study the blood clearance of microparticles in rats was used to investigate the effects of GSH-depleting electrophilic substances on the phagocytosis in vivo.
KeywordsHuman Serum Albumin Kupffer Cell Blood Clearance Resident Macrophage Hepatic Glutathione
Tc-99m-labeled millimicrospheres of human serum albumin
Unable to display preview. Download preview PDF.