Depletion of Hepatic Glutathione in Rats Impairs Phagocytosis In Vivo

  • G. Hennighausen
  • M. Engel
Conference paper
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 13)

Abstract

Glutathione is involved in the protection of phagocytes against oxidative damage and in the assembly and preservation of microtubules during phagocytosis (Voetmann et al 1980). The phagocytotic activity may be impaired by depletion of GSH in phagocytes. This may lead to a failure of unspecific and specific defense mechanisms, such as the clearance of microparticles from blood by Kupffer cells (Altura 1980), which are resident macrophages in the liver. In the present study the blood clearance of microparticles in rats was used to investigate the effects of GSH-depleting electrophilic substances on the phagocytosis in vivo.

Keywords

Albumin Glutathione Half Life Diethyl Paracetamol 

Abbreviations

CC

Colloidal carbon

DEM

Diethyl maleate

GSH

Reduced glutathione

MMS

Tc-99m-labeled millimicrospheres of human serum albumin

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References

  1. Altura BM (1980) Reticuloendothelial cells and host defense. Adv Microcirc 9: 252–294Google Scholar
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  5. Voetman AA, Loos JA, Roos D (1980) Changes in the levels of glutathione in phagocytosing human neutrophiles. Blood 55: 741–747PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • G. Hennighausen
    • 1
  • M. Engel
    • 1
  1. 1.Institute of Pharmacology and ToxicologyWilhelm-Pieck-University of RostockRostockGermany

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