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Protective Effect of Zinc Against Hepatotoxic Agents in the Rat Liver Slice System: Role of Metallothionein

  • U. Wormser
  • S. Ben-Zakine
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 13)

Abstract

The hepatocellular damage caused by toxic substances can be altered by metal pretreatment. It has been demonstrated that Zn-treated rats were more resistant to in vivo intoxication of carbon tetrachloride (CCl4) and cadmium (Cd) than control animals (Cagen and Klaassen 1979; Goering and Klaassen 1984). This phenomenon was attributed to increase in the intracellular level of a low molecular weight, Zn-induced protein with high content of metals and cysteine residues called metallothionein (MT).

Keywords

Carbon Tetrachloride Liver Slice Acute Toxicity Test Hepatocellular Damage Hepatotoxic Effect 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

MT

metallothionein

CCl4

carbon tetrachloride

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References

  1. Cagen SZ, Klaassen CD (1979) Protection of carbon tetrachloride-induced hepatotoxicity by zinc: role of metallothionein. Toxicol Appl Pharmacol 51: 107–116PubMedCrossRefGoogle Scholar
  2. Eaton DL, Toal BF (1982) Evaluation of the Cd/hemoglobin affinity assay for the rapid determination of metallothionein in biological tissues. Toxicol Appl Pharmacol 66: 134–142PubMedCrossRefGoogle Scholar
  3. Goering PL, Klaassen CD (1984) Zinc-induced tolerance to cadmium hepatotoxicity. Toxicol Appl Pharmacol 74: 299–307PubMedCrossRefGoogle Scholar
  4. Wormser U, Calp DA (1988) A rapid and reliable acute toxicity test for hepatotoxic agents using only a single animal. In: Goldberg AM (ed) Alternative Methods in Toxicology. Progress in In Vitro Toxicology, vol 6, Liebert, New York, pp 303–307Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • U. Wormser
    • 1
  • S. Ben-Zakine
    • 1
  1. 1.Dept. of PharmacologyThe Hebrew University-Hadassah Medical SchoolJerusalemIsrael

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