Protective Effect of Zinc Against Hepatotoxic Agents in the Rat Liver Slice System: Role of Metallothionein
The hepatocellular damage caused by toxic substances can be altered by metal pretreatment. It has been demonstrated that Zn-treated rats were more resistant to in vivo intoxication of carbon tetrachloride (CCl4) and cadmium (Cd) than control animals (Cagen and Klaassen 1979; Goering and Klaassen 1984). This phenomenon was attributed to increase in the intracellular level of a low molecular weight, Zn-induced protein with high content of metals and cysteine residues called metallothionein (MT).
KeywordsCarbon Tetrachloride Liver Slice Acute Toxicity Test Hepatocellular Damage Hepatotoxic Effect
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