Protective Effect of Zinc Against Hepatotoxic Agents in the Rat Liver Slice System: Role of Metallothionein

  • U. Wormser
  • S. Ben-Zakine
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 13)


The hepatocellular damage caused by toxic substances can be altered by metal pretreatment. It has been demonstrated that Zn-treated rats were more resistant to in vivo intoxication of carbon tetrachloride (CCl4) and cadmium (Cd) than control animals (Cagen and Klaassen 1979; Goering and Klaassen 1984). This phenomenon was attributed to increase in the intracellular level of a low molecular weight, Zn-induced protein with high content of metals and cysteine residues called metallothionein (MT).


Carbon Tetrachloride Liver Slice Acute Toxicity Test Hepatocellular Damage Hepatotoxic Effect 
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carbon tetrachloride


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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • U. Wormser
    • 1
  • S. Ben-Zakine
    • 1
  1. 1.Dept. of PharmacologyThe Hebrew University-Hadassah Medical SchoolJerusalemIsrael

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