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Metabolism and Endogenous Production of Ethylene in Rat and Man

  • J. Shen
  • W. Kessler
  • B. Denk
  • J. G. Filser
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 13)

Abstract

Ethylene (ET) is metabolized in rats to the carcinogenic ethylene oxide (EO) (Filser and Bolt 1983a). Since ET is produced in rats (Sagai and Ichinose 1980) and in humans (Ram Chandra and Spencer 1963), an endogenous risk from ET via EO has to be concluded. A prerequisite to quantitate the risk of ET is a detailed information on the pharmacokinetics and the production rate of ET in rat and man.

Keywords

Pharmacokinetic Parameter Ethylene Oxide Ethylene Oxide Body Burden Endogenous Production 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • J. Shen
    • 1
  • W. Kessler
    • 1
  • B. Denk
    • 1
  • J. G. Filser
    • 1
  1. 1.Institute of ToxicologyGesellschaft für Strahlen- und UmweltforschungNeuherbergGermany

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