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Metals — Epidemiological and Experimental Evidence for Carcinogenicity

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Biological Monitoring of Exposure and the Response at the Subcellular Level to Toxic Substances

Part of the book series: Archives of Toxicology ((TOXICOLOGY,volume 13))

Abstract

This paper mainly summarizes the epidemilogical evidence regarding the carcinogenicity of some metals. It may therefore be useful to recall the ideal requirements for establishing carcinogenicity from epidemiological evidence. Briefly, the positive association between exposure and cancer should not be explicable by bias in recording or detection, confounding or chance; it should vary appropriately with intensity and duration of exposure and time after exposure begins and ends and it should be observed repeatedly in different circumstances (Doll 1985).

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References

  • Axelson O, Dahlgren E, Janson CD, Rehnlund SA (1978) Arsenic exposure and mortality: a case-referent study from a Swedish copper smelter. Br J Ind Med 35: 8–15

    PubMed  CAS  Google Scholar 

  • Cooper WC, Wang O, Kheifets L (1985) Mortality among employees of lead battery plants and lead producting plants, 1947–1980. Scand J Work Environ Health 11: 331–345

    Article  PubMed  CAS  Google Scholar 

  • Doll R (1985) Relevance of epidemiology to policies for the prevention of cancer. Human Toxicology 4: 81–96

    Article  PubMed  CAS  Google Scholar 

  • Eiinder CG (1984) Health hazards from exposure to cobalt, with special reference to carcinogenic, mutagenic and teratogenic effects. Toxicol Environ Chem 7: 251–256

    Article  Google Scholar 

  • Eiinder CG, Kjellström T, Hogstedt C, Andersson K, Spang G (1985) Cancer mortality of cadmium workers. Br J Ind Med 42: 651–655

    Google Scholar 

  • Gerhardsson L, Lundrom NG, Nordberg G, Wall S (1986) Mortality and lead exposure: a retrospective cohort study of Swedish smelter workers. Br J Ind Med 43: 707–712

    PubMed  CAS  Google Scholar 

  • Goldberg M, Goldberg P, Leclerc A, Chastang JF, Fuhrer R, Brodeur JM, Segnan N, Floch JJ, Michel G (1987) Epidemiology of respiratory cancers related to nickel mining and refining in New Caledonia (1978–1984). Int J Cancer 40: 300–304

    Article  PubMed  CAS  Google Scholar 

  • Grandjean Ph, Andersen O, Nielsen G (1988) Carcinogenicity of occupational nickel exposures: an evaluation of the epidemiological evidence. Am J Ind Med 13: 193–209

    Article  PubMed  CAS  Google Scholar 

  • Groth DH, Stettier LE, Burg JR (1986) Carcinogenic effects of antimony trioxide and antimony ore concentrated in rats. J Toxicol Environ Health 18: 607–626

    Article  PubMed  CAS  Google Scholar 

  • HM Chief Inspector of Factories-Department of Employment. UK Annual Report 1974, HMSO, London 1975

    Google Scholar 

  • Hogstedt C, Alexandersson R (1987) Mortality among hard-metal workers in Sweden. Scand J Work Environ Health 13: 177–178

    Google Scholar 

  • Kazantzis G (1981) Role of cobalt, iron, lead, manganese, mercury, platinum, selenium, and titanium in carcinogenesis. Environ Health Perspect 40: 143–161

    Article  PubMed  CAS  Google Scholar 

  • Kusaka Y, Kuwabara O, Kitamura H (1984) A case of diffuse lung disease associated with lung cancer in a hard metal worker. Industrial Health, 22: 804–808

    CAS  Google Scholar 

  • Leonard A, Lauwerys R (1980 a) Carcinogenicity, teratogenicity and mutagenicity of arsenic. Mutat Res 75: 49–69

    Article  PubMed  CAS  Google Scholar 

  • Leonard A, Lauwerys R (1980 b) Carcinogenicity, and mutagenicity of chromium. Mutat Res 76: 227–239

    Article  PubMed  CAS  Google Scholar 

  • Mancuso TF (1980) Mortality study of beryllium industry workers, occupational lung cancer. Environ Res 21: 48–55

    Article  PubMed  CAS  Google Scholar 

  • Mao P, Molnar JJ (1967) The fine structure and histochemistry of lead-induced renal tumors in rats. Am J Pathol 50: 571–603

    PubMed  CAS  Google Scholar 

  • Mur JM, Moulin JJ, Charruyer-Seinerra MP, Lafitte J (1987a) A cohort mortality study among cobalt and sodium workers in an electrochemical plant. Am J Ind Med 11: 75–81

    Article  PubMed  CAS  Google Scholar 

  • Mur JM, Meyer-Bisch C, Pham QT, Massin N, Moulin JJ, Cavalier C, Sadoul P (1987b) Risk of lung cancer among iron ore miners: a proportional mortality study of 1075 deceased miners in Lorraine, France. J Occup Med 29: 762–768

    PubMed  CAS  Google Scholar 

  • Norseth T (1981) The carcinogenicity of chromium. Environ Health Perspect 40: 121–130

    Article  PubMed  CAS  Google Scholar 

  • Oldiges H, Glaser U, Hochrainer D (1987) Long-term inhalation study with four different cadmium compounds in rats p. 337–339 Heavy metals in the Environment vol. 1 (Ed. Lindberg S.E., Hutchinson T.) CEP consultants Ltd, Edinburgh.

    Google Scholar 

  • Ott MG, Holder BB, Gordon HL (1974) Respiratory cancer and occupational exposure to arsenicals. Arch Environ Health 29: 250–255

    PubMed  CAS  Google Scholar 

  • Pershagen G (1981) The carcinogenicity of arsenic. Environ Health Perspect 40: 93–100

    Article  PubMed  CAS  Google Scholar 

  • Pershagen G, Wall S, Taube A, Linnman L (1981) On the interaction between occupational arsenic exposure and smoking and its relationship to lung cancer. Scand J Work Environ Health 7: 302–309

    Article  PubMed  CAS  Google Scholar 

  • Pershagen G, Nordberg G, Björklund NE (1984) Carcinomas of the respiratory tract in hamsers given arsenic trioxide and/or benzo(a) pyrene by the pulmonary route. Environ Res 34: 227–241

    Article  PubMed  CAS  Google Scholar 

  • Skilleter DN (1987) Beryllium p 61–86 in Fishbein et al (eds) Genotoxic and carcinogenic metals: environmental and occupationel occurrence and exposure. Princeton Scientific Publishing CO, Princeton, USA

    Google Scholar 

  • Steinhoff D (1987) Institut für Toxikologie. Bayer AG, Wuppertal, FRG. Personal Letter

    Google Scholar 

  • Stokinger HE (1981) The metals. Antimony p 1505 In: Clayton DG, Clayton FE (eds). Patty’s Industrial Hygiene and Toxicology 3rd ed, Wiley Interscience, New York

    Google Scholar 

  • Sunderman FW Jr (1977) Metal carcinogenesis p 257–297. Advances in Modern Toxicology vol. 2 (Ed. Goyer RA, Mehlman MA) Hemisphere, Washington

    Google Scholar 

  • Sunderman FW Jr (1987) Physicochemical and biological attributes of nickel compounds in relationships to carcinogenic activities p 355–365 in Brown and Kodama (eds) Toxicology of Metals : Clinical and Experimental Research, John Willey & Sons, NY

    Google Scholar 

  • Wagoner JR, Infante PF, Bayliss DL (1980) Beryllium: an etiologic agent in the induction of lung cancer, nonneoplastic respiratory disease and heart disease among industrially exposed workers. Environ Res 21: 15–34

    Article  PubMed  CAS  Google Scholar 

  • Wehner AP, Busch RH, Olson RJ, Craig DK (1977) Chronic inhalation of cobalt oxide and cigarette smoke by hamsters. Am Ind Hyg Assoc J 38: 338–346

    Article  PubMed  CAS  Google Scholar 

  • Yamamoto A, Hisanaga A, Ishinishi N (1987) Tumorigenicity of inorganic arsenic compounds following intratracheal installations to the lungs of hamsters. Int J Cancer 40: 220–223

    Article  PubMed  CAS  Google Scholar 

  • Yamane Y, Sakai K (1973) Suppressive effect of concurrent administration of metal salts on carcinogenicity by dimethylaminoazobenzene and the effect of these metals on aminoazo dye metabolism during carcinogenesis. Gann 64: 563–567

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Unité de Toxicologie Industrielle et Médecine du Travail, Faculté de Médecine, Université Catholique de Louvain, 30.54. Clos Chapelle-aux-Champs, 1200, Bruxelles, Belgique

    R. R. Lauwerys

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  1. R. R. Lauwerys
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Editors and Affiliations

  1. Department of Pharmacology and Therapeutics, University of Dublin, Trinity College, Dublin 2, Ireland

    Philip L. Chambers  & Claire M. Chambers  & 

  2. Institut für Toxikologie, Gesellschaft für Strahlen- und Umweltforschung, Ingolstädter Landstraße 1, D-8042, Neuherberg, West Germany

    Helmut Greim

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© 1989 Springer-Verlag Berlin Heidelberg

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Lauwerys, R.R. (1989). Metals — Epidemiological and Experimental Evidence for Carcinogenicity. In: Chambers, P.L., Chambers, C.M., Greim, H. (eds) Biological Monitoring of Exposure and the Response at the Subcellular Level to Toxic Substances. Archives of Toxicology, vol 13. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74117-3_2

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  • DOI: https://doi.org/10.1007/978-3-642-74117-3_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-50336-1

  • Online ISBN: 978-3-642-74117-3

  • eBook Packages: Springer Book Archive

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