Gene Structure and Regulation of Cytochrome P-450

  • Y. Fujii-Kuriyama
  • A. Fujisawa-Sehara
  • K. Sogawa
Conference paper
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 13)

Abstract

Cytochrome P-450 is a collective term for a group of hemoproteins which catalyze monooxygenase reactions of steroids, fatty acids, prostaglandins and an almost infinite number of lipophilic xenobiotics. Generally speaking, most of the constituent members of the P-450 superfamily, if not all, are inducible enzymes. Their specific forms are induced in response to either endogenous or exogenous inducers.

Keywords

Electrophoresis Prostaglandin Glucocorticoid Acetyl Chloramphenicol 

Abbreviations

MC

3-methylcholanthrene

TCDD

phenobarbital, PB 2, 3, 7, 8-tetrachlorodibenzo-diox- in

CAT

chloramphenicol acelytransferase

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References

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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • Y. Fujii-Kuriyama
    • 1
    • 2
  • A. Fujisawa-Sehara
    • 1
    • 3
  • K. Sogawa
    • 1
    • 2
  1. 1.Department of BiochemistryCancer Institute, Japanese Foundation for Cancer ResearchToshima-ku, TokyoJapan
  2. 2.Department of Chemistry, Faculty of ScienceTohoku UniversitySendaiJapan
  3. 3.Division of Molecular GeneticsNational Institute of Neuroscience, NCNPKodaira, TokyoJapan

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