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Gene Structure and Regulation of Cytochrome P-450

  • Y. Fujii-Kuriyama
  • A. Fujisawa-Sehara
  • K. Sogawa
Conference paper
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 13)

Abstract

Cytochrome P-450 is a collective term for a group of hemoproteins which catalyze monooxygenase reactions of steroids, fatty acids, prostaglandins and an almost infinite number of lipophilic xenobiotics. Generally speaking, most of the constituent members of the P-450 superfamily, if not all, are inducible enzymes. Their specific forms are induced in response to either endogenous or exogenous inducers.

Keywords

Inducible Expression Upstream Regulatory Region Constituent Member Cryptic Form Xenobiotic Responsive Element 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

MC

3-methylcholanthrene

TCDD

phenobarbital, PB 2, 3, 7, 8-tetrachlorodibenzo-diox- in

CAT

chloramphenicol acelytransferase

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References

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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • Y. Fujii-Kuriyama
    • 1
    • 2
  • A. Fujisawa-Sehara
    • 1
    • 3
  • K. Sogawa
    • 1
    • 2
  1. 1.Department of BiochemistryCancer Institute, Japanese Foundation for Cancer ResearchToshima-ku, TokyoJapan
  2. 2.Department of Chemistry, Faculty of ScienceTohoku UniversitySendaiJapan
  3. 3.Division of Molecular GeneticsNational Institute of Neuroscience, NCNPKodaira, TokyoJapan

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