Critical Oxygen Delivery Levels During Shock

  • N. S. Faithfull
  • S. M. Cain
Conference paper


Whole body oxygen consumption (VO2) is not usually supply-limited until oxygen transport (QO2) is reduced below the critical oxygen delivery level (QO2c) when the oxygen extraction coefficient (OEC) becomes maximal and VO2 begins to decrease. QO2c can be approached by lowering blood oxygen capacity by haemodilution or decreasing oxygen content of the arterial blood by hypoxia. This has been shown to result in similar levels of QO2c, although the mixed venous partial pressures of oxygen (PvO2 at QO2c) were very different (Cain 1977). QO2c may also be reached when cardiac output is reduced following acute haemorrhage (Schwarz et al. 1981; Becker et al. 1985).


Oxygen Extraction Haemorrhagic Shock Tissue Oxygen Tension Improve Tissue Oxygenation Body Oxygen Consumption 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Becker L, Schumacker P, Nelson DP, Saltz SA, Rowland J, Long GR, Wood LDH (1985) Influence of FIO2 on the relationship between oxygen delivery and uptake (VO2) in the dog. Fed Proc 44: 809Google Scholar
  2. Biro GP (1982) Comparison of acute cardiovascular effects and oxygen-supply following haemodilution with dextran, stroma-free HB solution and FC suspension. Cardiovasc Res 16: 194–204PubMedCrossRefGoogle Scholar
  3. Biro GP (1983) Fluorocarbon and dextran hemodilution in myocardial ischaemia. Can J Surg 26: 163–168PubMedGoogle Scholar
  4. Cain SM (1977) Oxygen delivery and uptake in dogs during anemic and hypoxic hypoxia. J Appl Physiol 42: 228–234PubMedGoogle Scholar
  5. Chapler CK, Cain SM, Stainsby WN (1984) The effects of hyperoxia on oxygen uptake during acute anemia. Can J Physiol Pharmacol 62: 809–814PubMedCrossRefGoogle Scholar
  6. Clark A, Federspiel WJ, Clark PAA, Cokelet GR (1985) Oxygen delivery from red cells. Biophys J 47: 171–181PubMedCrossRefGoogle Scholar
  7. Clark LC, Moore RE, Diver S, Miller ML (1979) A new look at the vapour pressure problem in red cell substitutes. In: Proceedings of the 4 th international symposium on perfluorochemical blood substitutes. Excerpta Medica, Amsterdam, pp 55–67Google Scholar
  8. Dulling BR (1972)Microvascular responses to alterations in oxygen tension. Circ Res 31:481–489Google Scholar
  9. Erdmann W (1982) O2 diffusion coefficients. In: Frey R, Beisbarth H, Stossek K (eds) Oxygen carrying colloidal blood substitutes. Zuckschwerdt, Munich, p 143Google Scholar
  10. Faithfull NS, Erdmann W, Fennema M (1985) Oxygen tensions in the ischaemic myocardium following haemodilution with fluorocarbons or dextran. Br J Anaesth 57: 816–817 PCrossRefGoogle Scholar
  11. Fan F-C, Chen RYZ, Schluessler GB, Chien S (1980) Effects of hematocrit variations on regional haemodynamics and oxygen transport in the dog. Am J Physiol 238: H545 - H552PubMedGoogle Scholar
  12. Grote J, Steuer K, Muller R, Sontgerath C, Zimmer K (1985) O2 and CO2 solubility of the fluorocarbon emulsion Fluosol-DA 20% and O2 and CO2 dissociation curves of blood–Fluosol-DA 20% mixtures. Adv Exp Med Biol 191: 453–461PubMedGoogle Scholar
  13. Hellums JD (1977) The resistance to oxygen transport in the capillaries relative to that in the surrounding tissue. Microvasc Res 13: 131–136PubMedCrossRefGoogle Scholar
  14. Kolodgie FD, Dawson AK, Forman ME, Virmani R (1986) Effect of perfluorochemical (Fluosol-DA) on infarct morphology in dogs with permanent coronary artery occlusion. Virchows Arch [B] 119–134Google Scholar
  15. Krogh A (1919) The number and distribution of capillaries in muscles with calculations of the oxygen partial pressure head necessary for supplying the tissue. J Physiol 52: 409–415PubMedGoogle Scholar
  16. Lindbom L, Arfors K-E (1984) Non-homogeneous blood flow distribution in the rabbit tenuissimus muscle. Acta Physiol Scand 122: 225–233PubMedCrossRefGoogle Scholar
  17. Mellits DE (1968) Statistical methods. In: Cheek DB (ed) Human growth. Lea and Febiger, Philadelphia, pp 19–38Google Scholar
  18. Naito R, Yokoyama K (1978) Perfluorochemical blood substitutes. Green Cross, Osaka (Technical information series, no 6)Google Scholar
  19. Rasio EA, Goresky CA (1979) Capillary limitation of oxygen diffusion in the isolated rete mirabilis of the eel (Anguilla anguillaris). Circ Res 44: 498–503PubMedGoogle Scholar
  20. Rude RE, Golgar D, Khuri SF, Kloner RA, Karaffa S, Muller E, Clark LC, Braunwald E (1982) Effect of intravenous fluorocarbons during and without O2 enhancement on acute myocardial ischemic injury assessed by measurement of intramyocardial gas tensions. Am Heart J 103: 986–995PubMedCrossRefGoogle Scholar
  21. Rude RE, Bush LR, Tilton GD (1984) Effects of fluorocarbons with and without oxygen supplementation on cardiac hemodynamics and energetics. Am J Cardiol 54: 80–883CrossRefGoogle Scholar
  22. Schwarz S, Frantz RA, Shoemaker WC (1981) Sequential hemodynamic and oxygen transport responses in hypovolemia, anemia and hypoxia. J Appl Physiol 10 (241): H864 - H871Google Scholar
  23. Sinha AK (1969) Oxygen uptake and release by red cells through capillary wall and plasma layer. Thesis, University of California, San FranciscoGoogle Scholar
  24. Smith AR, van Alphen W, Faithfull NS, Fennema M (1985) Limb preservation in replantation surgery. J Plast Reconstr Surg 75: 227–237CrossRefGoogle Scholar
  25. Sutherland GR. Farrar MK, Peerless SJ (1984) Effect of Fluosol-DA on oxygen availability in focal cerebral ischemia. Stroke 15: 829–835PubMedCrossRefGoogle Scholar
  26. Zander R (1978) Oxygen transport by solutions for blood replacement in comparison with other infusion solutions. Klin Wochenschr 56: 567–573PubMedCrossRefGoogle Scholar
  27. Zander R, Makowski HV (1982) Life without haemoglobin? In: Frey R, Beisbarth H, Stossek K (eds) Oxygen carrying colloidal blood substitutes. Zuckschwerdt, Munich, pp 133–141Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • N. S. Faithfull
  • S. M. Cain

There are no affiliations available

Personalised recommendations