Critical Oxygen Delivery Levels During Shock
Whole body oxygen consumption (VO2) is not usually supply-limited until oxygen transport (QO2) is reduced below the critical oxygen delivery level (QO2c) when the oxygen extraction coefficient (OEC) becomes maximal and VO2 begins to decrease. QO2c can be approached by lowering blood oxygen capacity by haemodilution or decreasing oxygen content of the arterial blood by hypoxia. This has been shown to result in similar levels of QO2c, although the mixed venous partial pressures of oxygen (PvO2 at QO2c) were very different (Cain 1977). QO2c may also be reached when cardiac output is reduced following acute haemorrhage (Schwarz et al. 1981; Becker et al. 1985).
KeywordsCatheter Dioxide Ischemia Anemia Cardiol
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