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Insulin pp 169–181Cite as

Insulin Receptor Structure

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 92))

Abstract

The insulin receptor serves to not only concentrate insulin on the appropriate target cells, but also to initiate the responses of these cells to the hormone. Consequently, a great deal of research has been focused on this molecule. Early efforts were directed at quantitating the interaction of radioactively labeled insulin with its receptor (for reviews of these studies see GAMMELTOFT 1984; ROTH and GRUNFELD 1981 ; KAHN 1976). From these studies it was possible to

  1. 1

    Estimate the number of insulin receptors on different cells under various physiological conditions;

  2. 2

    Show that the interaction of insulin with its receptor results in a subsequent decrease in the number of cell surface receptors (the phenomenon called “downregulation”);

  3. 3

    Show that the interaction of insulin with its receptors is not a simple one since Scatchard plots of binding data were curvilinear, a phenomenon which has been interpreted to mean that insulin was interacting with two populations of receptors or that there was one class of receptors which exhibits negative cooperativity;

  4. 4

    Show that the rank order of potency of different insulin analogs varies in their binding to insulin receptors in different tissues, suggesting that the insulin receptor might differ in these tissues.

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Authors
  1. R. A. Roth
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Editors and Affiliations

  1. Pharmaceutical Research Division, Warner Lambert Company, 2800 Plymouth Road, Ann Arbor, MI, 48105, USA

    Pedro Cuatrecasas M. D. (President) (President)

  2. Division of Cell Biology, Burroughs Wellcome Co., Research Triangle Park, NC, 27709, USA

    Steven Jacobs M. D. (Director) (Director)

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© 1990 Springer-Verlag Berlin Heidelberg

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Roth, R.A. (1990). Insulin Receptor Structure. In: Cuatrecasas, P., Jacobs, S. (eds) Insulin. Handbook of Experimental Pharmacology, vol 92. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74098-5_9

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  • DOI: https://doi.org/10.1007/978-3-642-74098-5_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74100-5

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