Insulin pp 451-467 | Cite as

Insulin Regulation of Metabolism Relevant to Gluconeogenesis

  • R. Bressler
  • J. J. Bahl
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 92)


In this chapter the role of insulin in the regulation of intermediary metabolism relevant to gluconeogenesis and the glucostat function of the liver will be reviewed. Changes in plasma blood glucose levels are moderated by the actions of the liver primarily under the control of insulin and glucagon. Minimizing hyperglycemic and preventing hypoglycemic states requires short- and long-term regulation of hepatic and peripheral metabolism. An appreciation continues to develop of how the relevant biochemical pathways are regulated acutely at the level of enzyme activity and chronically through gene expression. Understanding the role of insulin in regulating the relevant intermediary metabolism requires discussion of hepatic glucose catabolism and anabolism and knowledge of the antagonistic actions of insulin and glucagon which are inseparable from the physiological functioning of the liver to maintain normal levels of blood glucose.


Fatty Acid Oxidation Pyruvate Carboxylase Hepatic Gluconeogenesis Hepatic Glucose Output Insulin Regulation 
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  1. Agius L, Chowdhury MH, Davis SN, Alberti KGMM (1986) Regulation of ketogenesis, gluconeogenesis, and glycogen synthesis by insulin and proinsulin in rat hepatocyte monolayer cultures. Diabetes 35:1286–1293PubMedGoogle Scholar
  2. Alberti KGMM, Christensen NJ, Christensen SE, Prange-Hansen AA, Iversen J, Lund-baek KA, Sever-Hansen K, Orskov H (1973) Inhibition of insulin secretion by somatostatin. Lancet 2:1299–1301PubMedGoogle Scholar
  3. Balks HJ, Jungermann K (1984) Regulation of the peripheral insulin/glucagon ratio by the liver. Eur J Biochem 141:645–650PubMedGoogle Scholar
  4. Barritt GJ, Zander GL, Utter M (eds) (1976) Gluconeogenesis. Its regulation in mammalian species. Wiley, New York, pp 3–46Google Scholar
  5. Bartels H, Vogt B, Jungermann K (1987) Glycogen synthesis from pyruvate in the peripor-tal and from glucose in the peri venous zone in perfused livers from fasted rats. FEBS Lett 221:277–283PubMedGoogle Scholar
  6. Bergman RN (1977) Integrated control of hepatic glucose metabolism. Fed Proc 36:256–261Google Scholar
  7. Berridge MJ (1984) Inositol triphosphate and diacylglycerol as second messengers. Biochemistry 220:345–352Google Scholar
  8. Bremer J, Osmundsen H (1984) Fatty acid oxidation and its regulation. In: Numa S (ed) Fatty acid metabolism and its regulation. Elsevier, Amsterdam, pp 113–154Google Scholar
  9. Bressler R (1970a) Physiological-chemical aspects of fatty acid oxidation. In: Wakil SJ (ed) Lipid metabolism. Academic, New York, pp 44–77Google Scholar
  10. Bressler R (1970b) Fatty acid oxidation. In: Florkin M, Stotz EH (eds) Lipid metabolism. Elsevier, Amsterdam, pp 331–359(Comprehensive biochemistry, vol 18)Google Scholar
  11. Brown WV, Ginsburg HH (1982) Diabetes and plasma lipoproteins. In: Brodoff BN, Bleicher SJ (eds) Diabetes mellitus and obesity. Williams and Wilkins, Baltimore, pp 192–199Google Scholar
  12. Cahill GF Jr (1971) Physiology of insulin in man. Diabetes 20:785–799PubMedGoogle Scholar
  13. Carlsten A, Hallgren B, Jagenburg R, Svanborg A, Werko L (1966) Amino acids and free fatty acids in plasma in diabetes. Acta Med Scand 179:361–369PubMedGoogle Scholar
  14. Carlsten A, Hallgren B, Jagenburg R, Svanborg A, Werko L (1967) Arterio-hepatic venous differences of free fatty acids and amino acids. Acta Med Scand 181:199–205PubMedGoogle Scholar
  15. Cherrington AD, Liljenquist JE (1981) Role of glucagon in regulating glucose production in vivo. In: Unger RH, Orci L (eds) Glucagon. Elsevier/North-Holland, New York, pp 221–253Google Scholar
  16. Cherrington AD, Chiasson JL, Liljenquist JE, Jennings AS, Keller U (1976) The role of insulin and glucagon in the regulation of basal glucose production in the postabsorptive dog. J Clin Invest 58:1407–1418PubMedGoogle Scholar
  17. Cherrington AD, Lacy WW, Chiasson JL (1978) Effect of glucagon on glucose production during insulin deficiency in the dog. J Clin Invest 62:664–677PubMedGoogle Scholar
  18. Cherrington AD, Diamond MP, Green DR, Williams PE (1982) Evidence for an in-trahepatic contribution in the waning of the effect of glucagon on glucose production in the conscious dog. Diabetes 31:917–922PubMedGoogle Scholar
  19. Cherrington AD, Stevenson RW, Steiner KE, Davis MA, Myers SR, Adkins BA, Abum-rad NH, Williams PE (1987) Insulin, glucagon and glucose as regulators of hepatic glucose uptake and production in vivo. Diabetes Metab Rev 3:307–332PubMedGoogle Scholar
  20. Chiasson JL, Cook J, Liljenquist JE, Lacy WW (1974) Glucagon stimulation of gluconeogenesis from alanine in the intact dog. Am J Physiol 227:19–23PubMedGoogle Scholar
  21. Chiasson JL, Liljenquist JE, Sinclair-Smith BC, Lacy WW (1975) Gluconeogenesis from alanine in normal postabsorptive man. Intrahepatic stimulatory effect of glucagon. Diabetes 24:574–584Google Scholar
  22. Chiasson JL, Liljenquist JE, Finger FE, Lacy WW (1976) Differential sensitivity of glycogenolysis anbd gluconeogenesis to insulin infusions in dogs. Diabetes 25:283–291PubMedGoogle Scholar
  23. Chiasson JL, Atkinson RL, Cherrington AD, Keller U, Sinclair-Smith BC, Lacy WW, Liljenquist JE (1979) Insulin regulation of gluconeogenesis from alanine in man. Diabetes 28:380Google Scholar
  24. Chiasson JL, Atkinson RL, Cherrington AD, Keller U, Sinclair-Smith BC, Lacy WW, Liljenquist JE (1980) Effects of insulin at two dose levels on gluconeogenesis from alanine in fasting man. Metabolism 29:810–818PubMedGoogle Scholar
  25. Christ B, Probst I, Jungermann K (1986) Antagonistic regulation of the glucose/glucose 6-phosphate cycle by insulin and glucagon in cultured hepatocytes. Biochem J 238:185–191PubMedGoogle Scholar
  26. Claus TH, Pilkis SJ (1981) Hormonal control of hepatic gluconeogenesis. In: Litwack G (ed) Biochemical actions of hormones, vol 8. Academic, New York, pp 209–271Google Scholar
  27. Cook GA, Nielsen RC, Hawkins RA, Mehlman MA, Laskshman MR, Veech RL (1977) Effect of glucagon on hepatic malonyl coenzyme A concentration and on lipid synthesis. J Biol Chem 252:4421–4424PubMedGoogle Scholar
  28. Dahhnan B, Schroeter C, Herbertz L, Reinauer H (1979) Myofibrillar protein, degradation and muscle proteinase in normal and diabetic rats. Biochem Med 21:33–39Google Scholar
  29. Davis MA, Williams PE, Cherrington AD (1985) Effect of glucagon on hepatic lactate metabolism in the conscious dog. Am J Physiol 248:463–470Google Scholar
  30. Delisle G, Fritz IB (1967) Interrelations between hepatic fatty acid oxidation and gluconeogenesis: a possible regulatory role of carnitine palmityltransferase. Proc Natl Acad Sci USA 58:790–797PubMedGoogle Scholar
  31. Eistetler K, Wolf PO (1982) Synthesis and hypoglycémic activity of phenylalkyloxirane-carboxylic acid derivatives. J Med Chem 25:109–113Google Scholar
  32. Exton JH (1972) Gluconeogenesis. Metabolism 21:945–990PubMedGoogle Scholar
  33. Exton JH (1979) Hormonal control of gluconeogenesis. In: Klachko DM, Anderson RR, Heimberg M (eds) Hormones and energy metabolism. Plenum, New York, pp 125–167Google Scholar
  34. Exton JH (1987) Mechanism of hormonal regulation of hepatic glucose metabolism. Diabetes Metab Rev 3:163–184PubMedGoogle Scholar
  35. Exton JH, Park CR (1965) Preliminary communication. J Biol Chem 240:PC955-PC957 Exton JH, Mallette LE, Jefferson LS, Wong EHA, Friedman N, Miller TB Jr, Park CR (1970) The hormonal control of hepatic gluconeogenesis. Recent Prog Horm Res 26:411–461Google Scholar
  36. Felig P (1973) The glucose-alanine cycle. Metabolism 22:179–207PubMedGoogle Scholar
  37. Felig P (1975) Amino acid metabolism in man. Annu Rev Biochem 44:933–955PubMedGoogle Scholar
  38. Felig P, Wahren J (1971) Influence of endogenous insulin secretion on splanchnic glucose and amino acid metabolism in man. J Clin Invest 58:1702–1711Google Scholar
  39. Felig P, Wahren J, Hendler R (1975) Influence of oral glucose ingestion on splanchnic glucose and gluconeogenic substrate metabolism in man. Diabetes 24:468–475PubMedGoogle Scholar
  40. Felig PE, Posefsky T, Marliss E, Cahill GF Jr (1970a) Alanine: key role in gluconeogenesis. Science 167:1003–1004PubMedGoogle Scholar
  41. Felig PE, Marliss, E, Ohman JL, Cahill GF (1970b) Plasma amino acid levels in diabetic ketoacidosis. Diabetes 19:727–736PubMedGoogle Scholar
  42. Felig P, Wahren J, Sherwin RS, Hendler R (1976) Insulin, glucagon and somatostatin in normal physiology and diabetes mellitus. Diabetes 25:1091–1099PubMedGoogle Scholar
  43. Felig P, Wahren J, Sherwin RS, Palaiologos G (1977) Protein and amino acid metabolism in diabetes mellitus. Arch Intern Med 137:507–512PubMedGoogle Scholar
  44. Fradkin J, Shamoon H, Felig P, Sherwin RS (1980) Evidence for an important role of changes in rather than absolute concentrations of glucagon in the regulation of glucose production in man. J Clin Endocrinol Metab 50:698–703PubMedGoogle Scholar
  45. Fröhlich J, Wieland O (1971) Glucagon and the permissive action of fatty acids in hepatic gluconeogenesis. Eur J Biochem 19:557–562PubMedGoogle Scholar
  46. Gerich J, Ldrenzi M, Bier D, Schneider V, Tsalikia E, Karam JH, Forsham PH (1975) Prevention of human diabetic ketoacidosis by somatostatin: evidence for an essential role of glucagon. N Engl J Med 292:985–989PubMedGoogle Scholar
  47. Granner DK, Sasaki K, Andreone T, Beale E (1986) Insulin regulates expression of the phosphoenolpyruvate carboxykinase gene. Recent Prog Horm Res 42:111–141PubMedGoogle Scholar
  48. Hagen JH (1963) The effect of insulin on the concentration of plasma glycerol. J Lipid Res 4:46–51PubMedGoogle Scholar
  49. Hartmann H, Probst I, Jungermann K, Creutzfeldt W (1987) Inhibition of glycogenolysis and glycogen phosphorylase by insulin and proinsulin in rat hepatocyte cultures. Diabetes 30:551–555Google Scholar
  50. Hems DA, Whitton PD (1973) Stimulation vasopressing of glycogen breakdown and gluconeogenesis in the perfused rat liver. Biochem J 136:705–709PubMedGoogle Scholar
  51. Hue L (1987) Gluconeogenesis and its regulation. Diabetes Metab Rev 3:111–126PubMedGoogle Scholar
  52. Ishida T, Chap Z, Chou J, Lewis R, Hartlev C, Entman M, Field JB (1983) Differential effects of oral peripheral intravenous and intraportal glucose on hepatic glucose uptake and insulin and glucagon extraction in conscious dogs. J Clin Invest 72:590–601PubMedGoogle Scholar
  53. Ivy JH, Svec M, Freeman S (1951) Free plasma levels and urinary excretion of eighteen amino acids in normal and diabetic dogs. Am J Physiol 167:182–188PubMedGoogle Scholar
  54. Jefferson LS, Robertson JW, Tolman EL (1973) Effects of hypophysectomy on lactate metabolism in the perfused rat liver. J Biol Chem 248:4561–4567PubMedGoogle Scholar
  55. Jennings AS, Cherrington AD, Liljenquist JE, Keller U, Lacy WW, Chiasson JL (1977) The roles of insulin and glucagon in the regulation of gluconeogenesis in the postabsorptive dog. Diabetes 26:849–856Google Scholar
  56. Jungermann K (1986) Functional heterogeneity of periportal and perivenous hepatocytes.Enzyme 35:161–180PubMedGoogle Scholar
  57. Khoo JC, Steinberg D, Thompson B (1973) Hormonal regulation of adipocyte enzymes the effects of epinephrine and insulin on the control of lipase, phosphorylase kinase, phosphorylase and glycogen synthetase. J Biol Chem 248:3823–3830PubMedGoogle Scholar
  58. Kilberg MS (1982) Amino acid transport in isolated rat hepatocytes. J Membr Biol 69:1–12PubMedGoogle Scholar
  59. Kletzien RF, Pariza MW, Becker JE (1975) Hormonal regulation of amino acid transport and gluconeogenesis in primary cultures of adult rat liver parenchymal cells. J Cell Physiol 89:641–646Google Scholar
  60. Koerker DJ, Ruch W, Chideckel E, Palmer J, Goodner CJ, Ensinck J, Gale CC (1974) Somatostatin: hypothalamic inhibitor of the endocrine pancreas. Science 184:482–484PubMedGoogle Scholar
  61. Komjati M, Bratusch-Marrain P, Waldhausl W (1986) Superior efficacy of pulsatile versus continuous hormone exposure on hepatic glucose production in vitro. Endocrinology 118:312–319PubMedGoogle Scholar
  62. Kraus-Friedmann N (ed) (1986) Hormonal control of gluconeogenesis, vol 1: Function and experimental approaches. CRC, Boca RatonGoogle Scholar
  63. Krebs HA (1964) Gluconeogenesis. Proc R Soc Lond [Biol] 159:545–564Google Scholar
  64. Lee SM, Bahl JJ, Bressler R (1985) Prevention of the metabolic effects of 2-tetradecylglycidate by octanoic acid in the genetically diabetic mouse (db/db). Biochem Med 33:104–109PubMedGoogle Scholar
  65. Lickley L, Kemmer F, Wasserman DH, Vranic M (1983) Glucagon and its relationship to other glucoregulatory hormones in exercise and stress in normal and diabetic subjects. In: Lefebvre PJ (ed) Glucagon II. Springer, Berlin Heidelberg New York, pp 297–350Google Scholar
  66. Liljenquist JE, Mueller GL, Cherrington AD, Keller U, Chiasson JL, Perry JM, Lacy WW, Rabinowitz D (1977) Evidence for an important role of glucagon in the regulation of hepatic glucose production in normal man. J Clin Invest 59:369–374PubMedGoogle Scholar
  67. Mahler R, Stafford WS, Tarrant ME (1964) The effect of insulin on lipolysis. Diabetes 18:297–302Google Scholar
  68. McGarry JD, Foster DW (1980) Regulation of hepatic fatty acid oxidation and ketone body production. Annu Rev Biochem 49:395–579PubMedGoogle Scholar
  69. McGarry JD, Foster DW (1981) Ketogenesis. In: Unger RH, Orci L (eds) Glucagon. El-sevier/North-Holland, New York, pp 273–295Google Scholar
  70. Menahan LA, Wieland O (1969) The role of thyroid function in the metabolism of perfused rat liver with particular reference to gluconeogenesis. Eur J Biochem 10:188–196PubMedGoogle Scholar
  71. Mohan C, Bessman SP (1985) Anabolic regulation of gluconeogenesis by insulin in isolated rat hepatocytes. Arch Biochem Biophys 242:563–573PubMedGoogle Scholar
  72. Mortimore GE, Mondon CE (1970) Inhibition by insulin of valine turnover in liver. J Biol Chem 245:2375–2383PubMedGoogle Scholar
  73. Newshohne EA, Stanley JC (1987) Substrate cycles: their role in control of metabolism with specific references to the liver. Diabetes Metab Rev 3:295–305Google Scholar
  74. Pariza MW, Butcher FR, Kletzien RF (1976) Induction and decay of glucagon induced amino acid transport in primary cultures of adult rat liver cells: paradoxical effects of cycloheximide and puromycin. Proc Natl Acad Sci USA 73:4511–4515PubMedGoogle Scholar
  75. Patton GS, Ipp E, Dobbs RE, Orci L, Vale W, Unger RH (1977) Pancreatic immunoreac-tive somatostatin release. Proc Natl Acad Sci USA 74:2140–2143PubMedGoogle Scholar
  76. Pilkis SJ, Park CR, Claus TH (1978) Hormonal control of hepatic gluconeogenesis. Vitam Horm 36:383–460PubMedGoogle Scholar
  77. Pilkis SJ, Chrisman TD, El-Maghrabi MR, Colosia A, Fox E, Pilkis J, Claus TH (1983) The action of insulin on hepatic fructose 2, 6-bisphosphate metabolism. J Biol Chem 258:1495–1503PubMedGoogle Scholar
  78. Probst I, Schwartz P, Jungermann K (1982) Induction in primary culture of “gluconeogenic” and “glycolytic” hepatocytes resembling periportal and perivenous cells. Eur J Biochem 126:271–278PubMedGoogle Scholar
  79. Randle PJ, Garland PB, Hales CN, Newshohne EA (1966) Interactions of metabolism and the physiological role of insulin. Recent Prog Horm Res 22:1–48PubMedGoogle Scholar
  80. Richards CS, Uyeda K (1982) Hormonal regulation of fructose-6-P, 2-kinase and fructose-2, 6-P2 by two mechanisms. J Biol Chem 257:8854–8861PubMedGoogle Scholar
  81. Rodbell M (1983) The actions of glucagon at its receptor: regulation of adenylate cyclase. In: Lefebvre P (ed) Glucagon I. Springer, Berlin Heidelberg New York, pp 263–290 (Handbook of experimental pharmacology, vol 66/1)Google Scholar
  82. Rodbell M (1985) Programmable messengers: a new theory of hormone action. Trends Biochem Sci 10:461–464Google Scholar
  83. Ruderman NB, Toews CJ, Shafrir E (1969) Role of free fatty acids in glucose homeostasis. Arch Intern Med 123:299–313PubMedGoogle Scholar
  84. Saggerson ED (1980) Regulation of lipid metabolism in adipose tissue and liver cells. In: Clemens MJ (ed) Biochemistry of cellular regulation. CRC, Boca Raton, pp 207–256Google Scholar
  85. Samols E, Marri G, Marks V (1965) Promotion of insulin secretion by glucagon. Lancet 2:415–416PubMedGoogle Scholar
  86. Samols E, Tyler JM, Marks V (1972) Glucagon-insulin interrelationships. In: Lefebvre PJ, Unger RH (eds) Glucagon: molecular physiology, clinical and therapeutic implications. Pergamon, Oxford, pp 151–173Google Scholar
  87. Scrutton MC, Utter MF (1968) The regulation of glycolysis and gluconeogenesis in animal tissue. Annu Rev Biochem 37:249–302Google Scholar
  88. Sestoft L, Trap-Jensen J, Lyngsoe J et al. (1977) Regulation of gluconeogenesis and ketogenesis during rest and exercise in diabetic subjects and normal men. Clin Sci Mol Med 53:411–418PubMedGoogle Scholar
  89. Shaw WA, Issekutz TB, Issekutz B Jr (1976) Gluconeogenesis from glycerol at rest and during exercise in normal diabetic, and methylprednisolone treated dogs. Metabolism 25:329–339PubMedGoogle Scholar
  90. Sherwin RS, Felig P (1977) Glucagon physiology in health and disease. In: McCann SM (ed) Endocrine physiology. Int Rev Physiol 16:151–171Google Scholar
  91. Sherwin RS, Hendler RG, Felig P (1976) Effect of diabetes mellitus and insulin on the turnover and metabolic response to ketones in man. Diabetes 25:776–784PubMedGoogle Scholar
  92. Singh SP, Snyder AK (1978) Effect of thyrotoxicosis on gluconeogenesis from alanine in the perfused rat liver. Endocrinology 102:182–187PubMedGoogle Scholar
  93. Soling HD, Willms B, Friedrichs D, Kleineke J (1968) Regulation of gluconeogenesis by fatty acid oxidation in isolated perfused livers of non-starved rats. Eur J Biochem 4:364–372PubMedGoogle Scholar
  94. Struck E, Ashmore J, Wieland O (1966) Effects of glucagon and long chain fatty acids on glucose production by isolated perfused rat liver. Adv Enzyme Regul 4:219–224PubMedGoogle Scholar
  95. Stucki JW, Bra Wand F, Walter P (1976) Regulation of pyruvate metabolism in rat liver mitochondria by adenine nucleotides and fatty acids. Eur J Biochem 27:181–191Google Scholar
  96. Taskinen MR, Nikkila EA (1979) Lipoprotein lipase activity of adipose tissue and skeletal muscle in insulin deficient human diabetes. Diabetologia 17:351–356PubMedGoogle Scholar
  97. Taunton DO, Stifel FB, Greene HL, Herman RH (1974) Rapid reciprocal changes in rat hepatic glycolytic enzyme and fructose diphosphatase activities following insulin and glucagon injection. J Biol Chem 249:7228–7239PubMedGoogle Scholar
  98. Tolman EL, Schworer CM, Jefferson LS (1973) Effects of hypophysectomy on amino acid metabolism and gluconeogenesis in the perfused rat liver. J Biol Chem 248:4552–4560PubMedGoogle Scholar
  99. Tutwiler GF, Dellevigne P (1979) Action of the oral hypoglycemic agent 2-tetradecylglycidic acid ion hepatic fatty acid oxidation and gluconeogenesis. J Biol Chem 254:2935–2944PubMedGoogle Scholar
  100. Tutwiler GF, Kirsch T, Morhbacher RJ, Ho W (1978) Pharmacologie profile of methyl 2-tetradecylglycide (McN-3716) an orally effective hypoglycemic agent. Metabolism 27:1539–1548PubMedGoogle Scholar
  101. Unger RH (1985) Glucagon physiology and pathophysiology in the light of new advances. Diabetologia 28:574–578PubMedGoogle Scholar
  102. Unger RH, Orci L (1981) Glucagon and the A cell. N Engl J Med 304:1518–1524, 1575-1580PubMedGoogle Scholar
  103. Utter MF, Scrutton MC (1969) Pyruvate carboxylase. Curr Top Cell Regul 1:253–296Google Scholar
  104. Von Glutz G, Walter P (1976) Regulation of pyruvate carboxylation by acetyl-CoA in rat liver mitochondria. FEBS Lett 72:299–303Google Scholar
  105. Wahren J, Hagenfeldt L, Felig P (1975) Splanchnic and leg exchange of glucose, amino acids and free fatty acids during exercise in diabetes mellitus. J Clin Invest 55:1303–1314PubMedGoogle Scholar
  106. Wahren J, Felig P, Hagenfeldt L (1976) Effect of protein ingestion on splanchnic and leg metabolism in normal man and in patients with diabetes mellitus. J Clin Invest 57:987–999PubMedGoogle Scholar
  107. Wakelam MJ, Murphy GJ, Hruby VJ, Houslay MD (1986) Activation of two signal-transduction system in hepatocytes by glucagon. Nature 323:68–71PubMedGoogle Scholar
  108. Wakil SJ, Stoops JK, Joshi VC (1983) Fatty acid synthesis and its regulation. Annu Rev Biochem 52:537–579PubMedGoogle Scholar
  109. Weber G (1972) Integrative action of insulin at the molecular level. In: Shafrir E (ed) Impact of insulin on metabolic pathways. Academic, New York, pp 151–166Google Scholar
  110. Weber G, Singhal RL, Srivastava SK (1965) Action of glucocorticoid as inducer and insulin as suppressor of biosynthesis of hepatic gluconeogenic enzymes. Adv Enzyme Regul 3:43–75Google Scholar
  111. Weber G, Singhal RL, Stamm NB, Lea MA, Fisher EA (1966) Synchronous behavior pattern of key glycolytic enzymes: glucokinase, phosphofructokinase and pyruvate kinase. Adv Enzyme Regul 4:59–81PubMedGoogle Scholar
  112. Weigle DS, Goodner CJ (1986) Evidence that the physiological pulse frequency of glucagon secretion optimizes glucose production by perifused rat hepatocytes. Endocrinology 118:1606–1613PubMedGoogle Scholar
  113. Weigle DS, Sweet IR, Goodner CJ (1987) A kinetic analysis of hepatocyte responses to a glucagon pulse: mechanism and metabolic consequences of differences in response decay times. Endocrinology 121:732–737PubMedGoogle Scholar
  114. White A, Handler P, Smith E, Hill R, Lehman IR (eds) (1978) Principles of biochemistry, 6th edn. McGraw-Hill, New YorkGoogle Scholar
  115. Whitton PD, Rodrigues LM, Hems DA (1978) Stimulation by vasopressin, angiotensin and oxytocin of gluconeogenesis in hepatocyte suspensions. Biochem J 176:893–898PubMedGoogle Scholar
  116. Williamson JR (1967) Effects of fatty acids, glucagon and anti-insulin serum on the control of gluconeogenesis and ketogenesis in rat liver. Adv Enzyme Regul 5:229–255PubMedGoogle Scholar
  117. Williamson JR, Browning ET, Olson MS (1968a) Interrelations between fatty acid oxidation and the control of gluconeogenesis in perfused rat liver. Adv Enzyme Regulation 6:67–100Google Scholar
  118. Williamson JR, Browning ET, Scholz R, Kreisberg RA, Fritz IB (1968b) Inhibition of fatty acid Stimulation of gluconeogenesis by (+)-decanoylcarnitine in perfused rat liver. Diabetes 17:194–208PubMedGoogle Scholar
  119. Willms B, Kleineke J, Soling HD (1970) The redox state of NAD/NADH systems in guinea pig liver during increased fatty acid oxidation. Biochim Biophys Acta 215:438–448PubMedGoogle Scholar
  120. Winegrad AI (1965) Adipose tissue in diabetes. In: Renold AE, Cahill GF Jr (eds) Adipose tissue. Williams and Wilkins, Baltimore, pp 319–329(Handbook of physiology, sect 5)Google Scholar
  121. Zierler KL, Rabinowitz D (1964) Effect of very small concentrations of insulin on forearm metabolism. Persistence of its actions on potassium and free fatty acids without an effect on glucose. J Clin Invest 43:950–962Google Scholar

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© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • R. Bressler
  • J. J. Bahl

There are no affiliations available

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