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Receptor-Mediated Internalization and Turnover

  • Chapter
Insulin

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 92))

Abstract

Binding of insulin to its specific cell surface receptor initiates a complicated array of events which encompass a variety of biochemical and physical steps. These include the generation of insulin’s pleiotropic biologic effects, as well as endocytotic uptake of the hormone-receptor complex. Insulin receptor internalization facilitates the process of hormone degradation and also initiates the steps of receptor uptake, intracellular traffic, and recycling; these latter events can be referred to as the insulin receptor itinerary. We will review some recent findings and the current state of knowledge concerning the insulin receptor itinerary and speculate about its function.

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Authors
  1. J. R. Levy
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  2. J. M. Olefsky
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Editor information

Editors and Affiliations

  1. Pharmaceutical Research Division, Warner Lambert Company, 2800 Plymouth Road, Ann Arbor, MI, 48105, USA

    Pedro Cuatrecasas M. D. (President) (President)

  2. Division of Cell Biology, Burroughs Wellcome Co., Research Triangle Park, NC, 27709, USA

    Steven Jacobs M. D. (Director) (Director)

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© 1990 Springer-Verlag Berlin Heidelberg

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Levy, J.R., Olefsky, J.M. (1990). Receptor-Mediated Internalization and Turnover. In: Cuatrecasas, P., Jacobs, S. (eds) Insulin. Handbook of Experimental Pharmacology, vol 92. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74098-5_12

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  • DOI: https://doi.org/10.1007/978-3-642-74098-5_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74100-5

  • Online ISBN: 978-3-642-74098-5

  • eBook Packages: Springer Book Archive

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