Insulin pp 209-236 | Cite as

The Insulin Receptor Tyrosine Kinase

  • P. Rothenberg
  • M. F. White
  • C. R. Kahn
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 92)


The insulin receptor is a tyrosine protein kinase. This enzymatic activity of the insulin receptor was first recognized in 1982, and is an initial, critical component of the mechanism by which insulin controls cell metabolism. Insulin binds to the extracellular domain of the receptor, activating the intracellular catalytic domain and triggering a unique sequence of tyrosine phosphorylations on the receptor and also on specific cellular protein substrates. While many of the precise molecular details and biological nuances of insulin receptor kinase function remain a challenging puzzle, significant new insights have been gleaned from the concentrated research efforts focused on this subject.


Insulin Receptor Tyrosine Kinase Activity Insulin Binding Human Insulin Receptor Insulin Receptor Tyrosine Kinase 
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© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • P. Rothenberg
  • M. F. White
  • C. R. Kahn

There are no affiliations available

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