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Insulin pp 3–22Cite as

Insulin Chemistry

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 92))

Abstract

Major aims of insulin chemistry are the large-scale production of the hormone for the treatment of diabetes mellitus as well as laboratory-scale syntheses of analogs for structure-function studies, of radioactive tracers, and of “tailormade” special derivatives. Further, one should include the detection and isolation of new native insulins and related compounds. The total synthesis, accomplished 25 years ago by the groups of ZAHN (MEIENHOFER et al. 1963), KATSOYANNIS (1964), and in China marked the advent of a new era in pep tide and protein chemistry. Remarkable progress has since been achieved through refinement of synthetic and semisynthetic procedures, the advances in recombinant DNA techniques, and high pressure liquid chromatography (HPLC).

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  1. D. Brandenburg
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  1. Pharmaceutical Research Division, Warner Lambert Company, 2800 Plymouth Road, Ann Arbor, MI, 48105, USA

    Pedro Cuatrecasas M. D. (President) (President)

  2. Division of Cell Biology, Burroughs Wellcome Co., Research Triangle Park, NC, 27709, USA

    Steven Jacobs M. D. (Director) (Director)

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© 1990 Springer-Verlag Berlin Heidelberg

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Brandenburg, D. (1990). Insulin Chemistry. In: Cuatrecasas, P., Jacobs, S. (eds) Insulin. Handbook of Experimental Pharmacology, vol 92. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74098-5_1

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  • DOI: https://doi.org/10.1007/978-3-642-74098-5_1

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