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Microbes Causing Problems of Antimicrobial Resistance

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Microbial Resistance to Drugs

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 91))

Abstract

The mainstay of therapy for both Staphylococcus aureus and coagulase negative staphylococci has been β-lactam antibiotics. Resistance to penicillin, normally the result of an inducible β-lactamase, is common in both groups. The β-lactamase is plasmid-specified and resistances to other compounds particularly heavy metals are frequently part of the same plasmid (reviewed by Brunton 1984). For practical purposes the widespread distribution of these enzymes and plasmids has rendered penicillin and other staphylococcal penicillinase-susceptible β-lactams ineffective for primary therapy of staphylococcal infections. Plasmids specifying β-lactamase belong to more than one incompatibility group (see Chap. 14, Taylor, this volume) and have been reported to also specify gentamicin resistance (Cohen et al. 1982).

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  1. L. E. Bryan
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  1. Department of Microbiology and Infectious Diseases, Faculty of Medicine, University of Calgary, Health Sciences Centre, 3330 Hospital Drive N.W., T2N 4N1, Calgary, Alberta, Canada

    Lawrence E. Bryan M.D., Ph. D., F.R.C.P. (C.) (Head) (Head)

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© 1989 Springer-Verlag Berlin Heidelberg

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Bryan, L.E. (1989). Microbes Causing Problems of Antimicrobial Resistance. In: Bryan, L.E. (eds) Microbial Resistance to Drugs. Handbook of Experimental Pharmacology, vol 91. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74095-4_18

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  • DOI: https://doi.org/10.1007/978-3-642-74095-4_18

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