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Methylation of RNA and Resistance to Antibiotics

  • E. Cundliffe
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 91)

Abstract

Microorganisms have evolved or acquired various modes of resistance to antibiotics, as discussed in depth in this volume. In some cases, active drug molecules may be physically prevented from encountering the target site(s) at which they normally act, either by direct exclusion at membrane barriers or by chemical inactivation due to extracellular enzymes (e.g. β-lactamases). In other instances, where total exclusion of the drug from the cytoplasm cannot be achieved, resistance may depend upon the operation of antibiotic efflux mechanisms (e.g. for tetracycline) or upon drug inactivation by intracellular enzymes and cofactors (e.g. for aminoglycosides). Thus, in some organisms, a critical balance may be struck between drug accumulation on the one hand and its removal or inactivation on the other, so that inhibitory drug concentrations are not established intracellularly.

Keywords

Ribosomal Ribonucleic Acid Translational Attenuation Methylase Protein ermC Gene Strain JR14 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Berlin Heidelberg 1989

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  • E. Cundliffe

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