Role of the Outer Membrane of Gram-Negative Bacteria in Antimicrobial Resistance

  • H. Nikaido
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 91)


The extensive use of antibiotics in recent years has been very effective in combating infections caused by “classical” pathogenic bacteria, but at the same time it produced an increase in infections, often hospital-acquired, by antibiotic-resistant gram-negative bacteria of moderate or even marginal pathogenicity (McGowan 1985). The general resistance to antibiotics, often encountered in such gram-negative bacteria, is largely due to the presence of an extra membrane layer on the surface of these organisms: the outer membrane of these bacteria acts as an effective permeation barrier and retards the influx of antibiotic molecules into the bacterial cell.


Outer Membrane Antimicrob Agent Outer Membrane Protein Serratia Marcescens Penetration Rate 
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© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • H. Nikaido

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