Neurochemical Aspects of Thermoregulation

  • R. D. Myers
  • T. F. Lee
Part of the Advances in Comparative and Environmental Physiology book series (COMPARATIVE, volume 4)


A quarter of a century has now elapsed since the announcement of the “monoamine theory” of thermoregulation. From an historical perspective, the concept put forward was that monoamines within the hypothalamus acted essentially in balanced but functional opposition to one another to bring about the precise control of one’s body temperature (Tb) (Feldberg and Myers 1963). Based initially on experiments utilizing intracerebroventricular (ICV) injection in the cat, serotonin (5-HT) was found to cause a rise in core temperature accompanied by the appropriate physiological responses for homeostatic thermogenesis including shivering and vasoconstriction. Conversely, norepinephrine (NE) or epinephrine (E) injected similarly not only attenuated the 5-HT-induced hyperthermia but also could lower the normal resting temperature of the cat (Feldberg and Myers 1964). Later, these effects were localized anatomically by micro-injection of the amines to the anterior hypothalamic, preoptic area (POAH) (Feldberg and Myers 1965), an area which is known to be involved in central thermoregulation.


Physiological Evidence Thermoregulatory Response Pharmacological Evidence Febrile Response Hypothermic Effect 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • R. D. Myers
    • 1
  • T. F. Lee
    • 2
  1. 1.Departments of Pharmacology and Psychiatric Medicine, East CarolinaUniversity School of MedicineGreenvilleUSA
  2. 2.Department of ZoologyUniversity of AlbertaEdmontonCanada

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