Natural Products Chemistry — Past and Future

  • K. Nakanishi
Part of the Springer Series in Wood Science book series (SSWOO)


As is true of other fields of science, natural products chemistry is in a state of transition and is undergoing a profound change in character. Being intimately related to nature and natural phenomena, plants, animals, food, poisons, diseases, etc., the “chemical” studies in the natural products area can be traced back thousands of years. Traditional natural products chemistry necessarily started with the isolation and purification of a compound, followed by structure determination, and culminated in partial or total synthesis.


Circular Dichroism Nuclear Overhauser Effect Resonance Raman Lithium Aluminum Hydride Natural Product Chemistry 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Anet F A L, Bourn A J R 1965 Effect of steric compression on coupling constants. J Am Chem Soc 87: 5249–5250CrossRefGoogle Scholar
  2. 2.
    Broughton H B, Ley S V, Slawin A M Z, Williams D J, Morgan E D 1986 X-Ray crystallographic structure determination of detigloyldihydroazadirachtin and reassignment of the structure of the limonoid insect antifeedant azadirachtin. J Chem Soc Chem Commun 46–47Google Scholar
  3. 3.
    Butterworth J H, Morgan E D, Percy G R 1972 The structure of azadirachtin; the functional groups. J Chem Soc Perkin Trans 1 2445–2450CrossRefGoogle Scholar
  4. 4.
    Chang C C, Nakanishi K 1983 Specionin, an iridoid insect antifeedant from Catalpa speciosa. J Chem Soc Chem Commun 605–606Google Scholar
  5. 5.
    Clarke H T, Johnson J R, Robinson R (eds) 1949 The chemistry of penicillin. Princeton Univ Press Princeton, 1094 ppGoogle Scholar
  6. 6.
    Fieser L F, Fieser M 1959 Steroids. Reinhold New York, 945 ppGoogle Scholar
  7. 7.
    Karrer P 1950 Organische Chemie. 4th English ed. Elsevier AmsterdamGoogle Scholar
  8. 8.
    Kraus W, Bokel M, Klenk A, Pohnl H 1985 The structure of azadirachtin and 22,23–dihydro-23/?-methoxyazadirachtin. Tetrahedron Lett 26: 6435–6438CrossRefGoogle Scholar
  9. 9.
    Maruyama M, Terahara A, Itagaki Y, Nakanishi K 1967 The ginkgolides. I. Isolation and characterization of the various groups. Tetrahedron Lett 299–302Google Scholar
  10. 10.
    Maruyama M, Terahara A, Itagaki Y, Nakanishi K 1967 The ginkgolides. II. Derivation of partial structures. Tetrahedron Lett 303–308Google Scholar
  11. 11.
    Maruyama M, Terahara A, Nakadaira Y, Woods M C, Nakanishi K 1967 The ginkgolides. III. The structure of the ginkgolides. Tetrahedron Lett 309–313Google Scholar
  12. 12.
    Maruyama M, Terahara A, Nakadaira Y, Woods M C, Takagi Y, Nakanishi K (1967) The ginkgolides. IV. Stereochemistry of the ginkgolides. Tetrahedron Lett 315–319Google Scholar
  13. 13.
    Nakanishi K 1967 The ginkgolides. Pure and Appl Chem 14: 89–113CrossRefGoogle Scholar
  14. 14.
    Nakanishi K, Goto T, Ito S, Naatori S, Nozoe S (eds) 1974 Natural products chemistry. Vol I. Kodansha Tokyo/Academic Press New York, 295–300Google Scholar
  15. 15.
    Nunez D, chignard M, Korth R, Le Couedich J P, Norel X, Spinnewyn B, Braquet P, Benveniste J 1986 Specific inhibition of PAF-acether-induced platelet activation by BN 52021 and comparison with the PAF-acether inhibitors kadsurenone and CV 3988. Eur J Pharmacol 123: 197–205PubMedCrossRefGoogle Scholar
  16. 16.
    Robinson R 1955 The structural relations of natural products. Clarenden Press Oxford, 144 ppGoogle Scholar
  17. 17.
    Schroeder D, Nakanishi K 1987 A simplified isolation procedure for azadirachtin. J Nat Prod (1987) 50: 241–244CrossRefGoogle Scholar
  18. 18.
    Taylor D A H 1984 The chemistry of the limonoids from Meliaceae. In: Herz W, Grisebach H, Kirby G W (eds) Progress in the chemistry of natural products. Vol 45. Springer, Berlin Heidelberg New York Tokyo, 1–102Google Scholar
  19. 19.
    Taylor D A H 1987 Azadirachtin. Tetrahedron 43: 2779–2787CrossRefGoogle Scholar
  20. 20.
    Van der Eycken E, De Bruyn A, Van der Eycken J, Callant P, Vandewalle M 1986 Iridoids: The structure elucidation of specionin based on chemical evidence and NMR analysis. Tetrahedron 42: 5385–5396CrossRefGoogle Scholar
  21. 21.
    Woods M C, Miura I, Nakadaira Y, Terahara A, Maruyama M, Nakanishi K 1967 The ginkgolides. V. Some aspects of their NMR spectra. Tetrahedron Lett 321–326Google Scholar
  22. 22.
    Woodward R B 1941 Structure and absorption spectra of a?-unsaturated ketones. J Am Chem Soc 63: 1123–1126CrossRefGoogle Scholar
  23. 23.
    Woodward R B 1942 Structure and absorption spectra. III. Normal conjugated dienes. J Am Chem Soc 64: 72–75CrossRefGoogle Scholar
  24. 24.
    Woodward R B 1942 Structure and absorption spectra. IV. Further observations on unsaturated ketones. J Am Chem Soc 64: 76–77CrossRefGoogle Scholar
  25. 25.
    Zanno P, Miura I, Nakanishi K, Elder D L 1975 Structure of the insect phagorepellent azadirachtin. Application of PRFT/CWD carbon-13 nuclear magnetic resonance. J Am Chem Soc 97: 1975–1977PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • K. Nakanishi

There are no affiliations available

Personalised recommendations