Methods for Assessing the Effect of Drugs on Hair and Nails

  • R. P. R. Dawber
  • N. B. Simpson
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 87 / 2)

Abstract

The complaint of hair loss may be related to an increased shedding rate or a decrease in the number of hairs per unit area (Rook and Dawber 1982). Apparent thinning of hair may relate to a decrease in hair numbers, in hair diameter or reduction of pigment. Microscopy or measurements will detect objective changes before the patient or physician is aware of any abnormality.

Keywords

Clay Permeability Lithium Testosterone Baran 

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References

  1. Adachi K, Uno H (1968) Glucose metabolism of growing and resting human hair follicles. Am J Physiol 215:1234–1239PubMedGoogle Scholar
  2. Baran R, Dawber RPR (1984) Diseases of the nails and their management, 1st edn. Black-well, OxfordGoogle Scholar
  3. Barman JM, Pecoraro V, Astore I (1964) Method, technique and computations in the study of the trophic state of human scalp hair. J Invest Dermatol 42:421–425PubMedGoogle Scholar
  4. Braun-Falco O (1966) Dynamik des normalen und pathologischen Haarwachstums. Arch Klin Exp Dermatol 227:419–452PubMedGoogle Scholar
  5. Brown AC, Crounse RG (1980) Hair, trace elements and human illness. Praeger, New YorkGoogle Scholar
  6. Comaish S (1969) Autoradiographic studies of hair growth in various dermatoses: investigation of a possible circadian rhythm in human hair growth. Br J Dermatol 81:283–288PubMedCrossRefGoogle Scholar
  7. Dawber RPR (1970) The effect of methotrexate, corticosteroids and azathioprine on fingernail growth in psoriasis. Br J Dermatol 83:680–683PubMedCrossRefGoogle Scholar
  8. Dawber RPR, Mortimer PS (1982) Hair loss during lithium treatment. Br J Dermatol 197:124–125CrossRefGoogle Scholar
  9. Dawber RPR, Sonnex T, Ralfs I (1982) Antiandrogen treatment of common baldness in women. Br J Dermatol 107:247CrossRefGoogle Scholar
  10. Ebling FJ, Thomas AK, Cooke ID, Randall VA, Skinner J, Cawood M (1977) Effect of cyproterone acetate on hair growth, sebaceous secretion and endocrine parameters in a hirsute subject. Br J Dermatol 97:371–381PubMedCrossRefGoogle Scholar
  11. Ferriman D, Gallway JD (1961) Clinical assessment of body hair growth in women. J Clin Endocrinol Metab 21:1440–1447PubMedCrossRefGoogle Scholar
  12. Gammeltoft M, Wulf HC (1980) The transmission of 12 kV Grenz rays and 29 kV X-rays through normal and diseased nails. Acta Derm Verereol (Stockh) 60:431–432Google Scholar
  13. Gibbons RD, Fiedler-Weiss VC, West DP, Lepin G (1986) Quartification of scalp hair -a computer-aided methodology. J Invest Dermatol 86:78–82PubMedCrossRefGoogle Scholar
  14. Green MR, Clay CS, Gibson WT, Hughes TC, Smith CG, Westgate GE, White M, Kealey T (1986) Rapid isolation in large numbers of intact, viable, individual hair follicles from skin: biochemical and ultrastructural characterisation. J Invest Dermatol 87:768–770PubMedCrossRefGoogle Scholar
  15. Grey LJ, Bowlt C (1978) An attempt to use thermally stimulated currents in human nail to estimate dose in case of accidental exposure to ionizing radiation. Phys Med Biol 23:759–760PubMedCrossRefGoogle Scholar
  16. Home KA, Jahoda CAB, Oliver RF (1986) Whisker growth induced by implantation of cultured vibrissa dermal papilla cells in the adult rat. J Embryol Exp Morphol 97:111–124Google Scholar
  17. Jackson D, Church R, Ebling F (1972) Hair diameter in female baldness. Br J Dermatol 87:361–367PubMedCrossRefGoogle Scholar
  18. Jahoda CAB, Oliver RF (1981) The growth of vibrissa dermal papilla cells in vitro. Br J Dermatol 105:623–627PubMedCrossRefGoogle Scholar
  19. Katz M, Wheeler KE, Radowsky M, Gordon W (1979) Assessment of rate of hair growth using a simple trichometer. Med Biol Eng Comput 17:333–336PubMedCrossRefGoogle Scholar
  20. Limat A, Noser FK (1986) Serial cultivation of single keratinocytes from the outer root sheath of human scalp hair follicles. J Invest Dermatol 87:485–488PubMedCrossRefGoogle Scholar
  21. Maudelonde T, Rosenfield RL, Shuter CF, Schwartz SA (1986) Studies of androgen metabolism and action in cultured hair and skin cells. J Steroid Biochem 24:1053–1060PubMedCrossRefGoogle Scholar
  22. Messenger AG (1984) The culture of dermal papilla cells from human hair follicles. Br J Dermatol 110:685–689PubMedCrossRefGoogle Scholar
  23. Munro DD (1966) Hair growth measurement using intradermal sulfur 35 cystine. Arch Dermatol Syphilol 93:119–122CrossRefGoogle Scholar
  24. Murad S, Hodgins MB, Simpson NB, Oliver RF, Jahoda C (1985) Androgen receptors and metabolism in cultured dermal papilla cells from human hair follicles (Abstr). Br J Dermatol 113:768Google Scholar
  25. Murad S, Hodgins MB, Oliver RF, Jahoda C (1986) Comparative studies of androgen receptors and metabolism in dermal papilla cells cultured from human and rat hair follicles (Abstr). J Invest Dermatol 87:158Google Scholar
  26. Norton LA (1971) Incorporation of thymidine methyl 3H and glycine 23H in the nail matrix and bed of humans. J Invest Dermatol 56:61–68PubMedCrossRefGoogle Scholar
  27. Parker SG, Diffey BL (1983) The transmission of optical radiation through human nails. Br J Dermatol 108:11–16PubMedCrossRefGoogle Scholar
  28. Peereboom-Wynia JDR (1981) Comparative studies of the diameters of hair shafts in an-agen and in telogen phases in male adults without alopecia and in male adults with an-drogenetic alopecia. In: Orfanos CE, Montagna W, Stuttgen G (eds) Hair research. Springer, Berlin Heidelberg New YorkGoogle Scholar
  29. Ralfs I, Dawber RPR, Ryan TJ, Wright NA (1982) The epidermal cell kinetics of the erythrokeratodermas. Br J Dermatol 107:565–567PubMedCrossRefGoogle Scholar
  30. Rook A, Dawber R (1982) Diseases of the hair and scalp. Blackwell, LondonGoogle Scholar
  31. Rushton J, James KC, Mortimer CH (1983) The unit area trichogram in the assessment of androgen-dependent alopecia. Br J Dermatol 109:429–438PubMedCrossRefGoogle Scholar
  32. Saitoh M, Uzaka M, Sakamoto M, Kobori M (1969) Rate of hair growth. In: Montagna W, Dobson RL (eds) Hair growth. Pergamon, Oxford, pp 183–201 (Advances in biology of skin, vol 9)Google Scholar
  33. Saitoh M, Uzaka M, Sakamoto M (1970) Human hair cycle. J Invest Dermatol 54:65–81PubMedCrossRefGoogle Scholar
  34. Schweikert HU, Wilson JD (1974 a) Regulation of human hair growth by steroid hormones. I. Testosterone metabolism in isolated hairs. J Clin Endocrinol Metab 38:811–819PubMedCrossRefGoogle Scholar
  35. Schweikert HU, Wilson JD (1974 b) Regulation of human hair growth by steroid hormones. II. Androstenedione metabolism in isolated hairs. J Clin Endocrinol Metab 39:1012–1019PubMedCrossRefGoogle Scholar
  36. Schweikert HU, Milewich L, Wilson JD (1975) Aromatisation of androstenedione by isolated human hairs. J Clin Endocrinol Metab 40:313–417CrossRefGoogle Scholar
  37. Sims RT, Hall T (1968) X-ray emission microanalysis of the density of hair proteins in kwashiorkor. Br J Dermatol 80:335–338Google Scholar
  38. Stüttgen G, Bauer E (1981) Bioavailability, skin and nail penetration of topically applied antimycotics. Mykosen 25:74–80Google Scholar
  39. Walters KA, Flynn GL, Marvel JR (1981) Physiochemical properties of the human nail. J Invest Dermatol 76:76–79PubMedCrossRefGoogle Scholar
  40. Weinstein GD, Mooney K (1980) Cell proliferation kinetics in the human hair root. J Invest Dermatol 74:43–46PubMedCrossRefGoogle Scholar
  41. Wells J (1982) A simple technique for establishing cultures of epithelial cells. Br J Dermatol 107:481–482PubMedCrossRefGoogle Scholar
  42. Wetterings PJJM, Vermorken AJM, Bloemendal J (1981) A method for culturing human hair follicle cells. Br J Dermatol 104:1–5CrossRefGoogle Scholar
  43. Wright NA (1980) The kinetics of human epidermal cell populations in health and disease. In: Rook AJ, Savin JA (eds) Recent advances in dermatology 5. Livingstone, Edinburgh, pp 317–343Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • R. P. R. Dawber
  • N. B. Simpson

There are no affiliations available

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