Abstract
The importance of zinc deficiency was not fully appreciated until Moynahan (1974), associated it with acrodermatitis enteropathica, a potentially fatal disorder of infants. Devotion of a chapter of this book to zinc reflects its particular importance for the skin and I will particularly review those situations where zinc may be of therapeutic value; excellent reviews of the metabolic role of zinc are Aggett and Harries (1979), Chesters (1980) and Weismann (1980).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Aggett PJ, Harris JT (1979) Current status of zinc in health and disease states. Arch Dis Child 54:909–918
Aggett PJ, Atherton DJ, More J, Davey J, Delves HT, Harries JT (1980) Symptomatic zinc deficiency in a breast-fed pre-term infant. Arch Dis Child 55:547–550
Antoniou LD, Shalhoub RJ, Sudhaker T, Smith JC Jr (1977) Reversal of uraemic impotence by zinc. Lancet 2:895–898
Ashrafi SH, Meyer J, Squier CA (1980) Effects of zinc deficiency on the distribution of membrane-coating granules in rat buccal epithelium. J Invest Dermatol 74:425–432
Atherton DJ, Miller DPR, Aggett PJ, Harries JT (1979) A defect in zinc uptake by jejuna biopsies in acrodermatitis enteropathica. Clin Sci 56:505–507
Baer MT, King JC, Tamura T, Margen S (1978) Acne in zinc deficiency. Arch Dermatol 114:1093
Barcia PJ (1970) Lack of acceleration of healing with zinc sulphate. Ann Surg 172:1048–1050
Brody I (1981) Topical treatment of recurrent herpes simplex and post-herpetic erythema multiforme with low concentrations of zinc sulphate solution. Br J Dermatol 104:191–194
Brook AC, Johnston DG, Ward MK, Watson M J, Cook DB, Kerr DNS (1980) Absence of a therapeutic effect of zinc in the sexual dysfunction of haemodialysed patients. Lancet 2:618–620
Chesters JK (1980) Biochemical functions of zinc in animals. World Rev Nutr Diet 32:135–164
Chvapil M (1976) Effects of zinc on cells and biomembranes. Med Clin North Am 60:799–812
Cousins RJ, Smith KT (1980) Zinc binding properties of bovine and human milk in vitro: influence of changes in zinc content. Am J Clin Nutr 33:1083–1087
Cunliffe WJ, Burke B, Dodman B, Gould DJ (1979) A double-blind trial of zinc sulphate/citrate complex and tetracycline in the treatment of acne vulgaris. Br J Dermatol 101:321–325
Cunnane SC, Horro bin DF (1980) Parenteral linoleic and γ-linoleic acids ameliorate the gross effects of zinc deficiency. Proc Soc Exp Biol Med 164:583–588
Dauncey J, Shaw JCL, Urman J (1977) The absorption and retention of magnesium, zinc and copper by low birth weight infants fed pasteurised human milk. Pediatr Res 11:991–997
Evans GW, Johnson PE (1980) Characterization and quantitation of zinc-binding ligand in human milk. Pediatr Res 14:876–880
Fridlender B, Chejanovsky N, Becker Y (1978) Selective inhibition of herpes simplex virus type I DNA polymerase by zinc ions. Virology 84:551–554
Good RA, Fernandez G, West A (1979) Nutrition, immunity and cancer — a review. Part I: influence of protein or protein-calorie malnutrition and zinc deficiency on immunity. Clin Bull 9:3–12
Greaves MW, Boyde TRC (1967) Plasma zinc concentrations in patients with psoriasis, dermatoses and venous leg ulceration. Lancet 2:1019–1020
Greaves MW, Ive FA (1972) Double-blind trial of zinc sulphate in the treatment ochronic venous leg ulceration. Br J Dermatol 87:632–634
Hallbook T, Lanner E (1972) Serum zinc and healing of venous leg ulcers. Lancet 2:780–782
Hambidge KM, Chaves MN, Brown RM, Walravens PA (1978) Zinc supplementation of low-income pre-school children. In: Kirchgessner M (ed) Trace element metabolism in man and animals, vol 3. Technische Universität, München, Freising-Weihenstephan, pp 296–299
Hawkins T, Marks JM, Plummer VM, Greaves MW (1976) Whole body monitoring and other studies of zinc 65 metabolism in patients with dermatological diseases. Clin Exp Dermatol 1:243–252
Hooper PL, Visconti L, Garry PH, Johnson GE (1980) Zinc lowers high density protein-cholesterol levels. JAMA 244:1960–1961
Husain SL (1969) Oral zinc sulphate in leg ulcers. Lancet 1:1069–1071
Klingberg WG, Prasad AS, Oberleas D (1976) Zinc deficiency following penicillamine therapy. In: Prasad AS, Oberleas D (eds) Trace elements in human helath and diseae, vol 1. Academic, New York, pp 51–65
Lancet (1978) Editorial: A radical approach to zinc. Lancet i:191–192
Love AHG, Elmes M, Golden MJ, McMaster D (1978) Zinc deficiency and coeliac disease. In: Kirchgessner (ed) Trace element metabolism in man and animals. Technische Universität München, Freising-Weihenstephan, pp 357–362
Mahajan SK, Prasad AS, Lambujon J, Abbasi AA, Briggs WA, McDonald FD (1980) Improvement of uremic hypogeusia by zinc: a double-blind study. Am J Clin Nutr 33:1517–1521
McClain C, Soutor C, Zieve L (1980) Zinc deficiency: a complication of Crohn’s disease. Gastroenterology 78:272–279
Michaelsson G, Ljunghall K, Danielson BG (1980) Zinc in epidermis and dermis in healthy subjects. Acta Dermato Venereol (Stockh) 60:295–299
Morgan MEI, Hughes MA, McMillan EM, King I, Mackie RM (1980) Plasma zinc in psoriasis in patients treated with local zinc applications. Br J Dermatol 102:579–583
Moynahan EJ (1974) Acrodermatitis enteropathica: a lethal inherited human zinc deficiency disorder. Lancet 1:399–400
Murphy JV (1970) Intoxication following ingestion of elemental zinc. JAMA 212:2119–2120
Nishi Y, Lifshitz F, Bayne MA, Daum F, Silverberg M, Aiges H (1980) Zinc status and its relation to growth retardation in children with chronic inflammatory bowel disease. Am J Clin Nutr 33:2613–2621
Oberleas D, Harland BF (1977) Nutritional agents which affect metabolic zinc status. In: Brewer GJ, Prasad AS (eds) Zinc metabolism: current aspects in health and disease. Liss, New York, pp 11–24
Phillips A, Davidson M, Greaves MW (1977) Venous leg ulceration: evaluation of zinc treatment, serum zinc and rate of healing. Clin Exp Dermatol 2:395–399
Piletz JE, Ganschow RW (1978) Lethal milk mutation results in dietary zinc deficiency in nursing mice. Am J Clin Nutr 31:560–562
Pories WJ, Henzel JH, Rob CG, Strain WH (1967) Acceleration of wound healing in man with zinc sulphate given by mouth. Lancet 1:121–124
Prasad AS, Brewer GJ, Schoomaker EB, Rebbani P (1978) Hypocupraemia induced by zinc therapy in adults. JAMA 240:2166–2168
Russell RM (1980) Vitamin A zinc metabolism in alcoholism. Am J Clin Nutr 33:2741–2749
Sandstead HH (1973) Zinc nutrition in the United States. Am J Clin Nutr 26:1251–1260
Seltzer JL, Jeffrey JJ, Eisen AZ (1977) Evidence for mammalian collagenases as zinc ion metalloenzymes. Biochim Biophys Acta 485:179–187
Solomons NW, Russel RM (1980) The interaction of vitamin A and zinc: implications for nutrition. Am J Clin Nutr 33:2031–2040
Tennican P, Carl G, Frey J, Thies L, Chvapil M (1980) Topical zinc in the treatment of mice infected intravaginally with herpes genitalis virus. Proc Soc Exp Biol Med 164:593–597
Thorn JM, Aggett PJ, Delves HT, Clayton BE (1978) Mineral and trace element supplement for use with synthetic diets based on comminuted chicken. Arch Dis Child 53:931–938
Verma KC, Saini AS, Dhamija SK (1980) Oral zinc sulphate therapy in acne vulgaris: a double-blind trial. Acta Derm Venereol (Stockh) 60:337–340
Wahba A (1980) Topical application of zinc solutions: a new treatment for herpes simplex infections in the skin. Acta Derma Venereol (Stockh) 60:175–177
Walravens PA, Hambidge KM (1976) Growth of infants fed a zinc supplemented formula. Am J Clin Nutr 29:1114–1121
Webster PO (1980) Urinary zinc excretion during treatment with different diuretics. Acta Med Scand 208:209–212
Weismann K (1980) Zinc metabolism and the skin. In: Rook, Savin (eds) Recent advances in dermatology, vol 5. Churchill Livingstone, Edinburgh, pp 109–129
Weismann K, Hoyer H, Christensen E (1980) Acquired zinc deficiency in alcoholic cirrhosis: report of 2 cases. Acta Derm Venereol (Stockh) 60:447–449
Widdowson EM, Dauncey J, Shaw JCL (1974) Trace elements in foetal and early postnatal development. Proc Nutr Soc 33:275–284
Zimmermann AW, Hambidge KM, Lepow ML, Greenberg RD, Stover ML, Casey CE (1982) Acrodermatitis in breast fed premature infants: evidence for a defect of mammary zinc secretion. Pediatrics 69:176–183
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Atherton, D.J. (1989). Zinc Deficiency. In: Greaves, M.W., Shuster, S. (eds) Pharmacology of the Skin II. Handbook of Experimental Pharmacology, vol 87 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74054-1_40
Download citation
DOI: https://doi.org/10.1007/978-3-642-74054-1_40
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-74056-5
Online ISBN: 978-3-642-74054-1
eBook Packages: Springer Book Archive