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Dapsone and Sulphapyridine

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Pharmacology of the Skin II

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 87 / 2))

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Abstract

Dermatitis herpetiformis (DH) is a chronic vesiculobullous disorder, involving an intensely itchy papulovesicular eruption of the skin. Both dapsone (4,4′-diamino-diphenylsulphone, DDS) and sulphapyridine (SP), two chemically related drugs, quickly relieve the itching and dramatically bring the skin lesions under control.

What has fascinated dermatologists for over 30 years is why sulphapyridine and dapsone have such a remarkable effect on dermatitis herpetiformis

(Alexander 1975)

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Authors
  1. T. M. Twose
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Editors and Affiliations

  1. The Institute of Dermatology, St. Thomas’s Hospital, Lambeth Palace Road, SE1 7EH, London, Great Britain

    Malcolm W. Greaves M.D., Ph.D., F.R.C.P.

  2. Department of Dermatology, The Royal Victoria Infirmary, The University of Newcastle upon Tyne, NE1 4LP, Newcastle upon Tyne, Great Britain

    Sam Shuster M.D., Ph. D., F.R.C.P.

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© 1989 Springer-Verlag Berlin Heidelberg

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Twose, T.M. (1989). Dapsone and Sulphapyridine. In: Greaves, M.W., Shuster, S. (eds) Pharmacology of the Skin II. Handbook of Experimental Pharmacology, vol 87 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74054-1_39

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  • DOI: https://doi.org/10.1007/978-3-642-74054-1_39

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74056-5

  • Online ISBN: 978-3-642-74054-1

  • eBook Packages: Springer Book Archive

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