Drugs Acting on Dermal Connective Tissue

  • B. Nusgens
  • C. M. Lapière
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 87 / 2)


The dermis is a complex tissue composed of differentiated fibroblasts embedded in an extracellular matrix containing various macromolecules: collagens, proteoglycans, elastin and glycoproteins. Interactions between these various constituents and with the cells determine the architectural organisation and the function of the supporting network. The different steps and their potential controls operating in the synthesis, degradation and organisation of these molecules are described in Chap. 9. Each of these steps can potentially be modified or modulated by exogenous agents. The discovery of pharmacological agents active in some of them and the knowledge of their mode of action has helped to elucidate physiological mechanisms. Much of the information about the pharmacology of the dermis is related to fibroblasts and mainly one of their biosynthetic products, collagen. This protein will be considered as a model compound to monitor the activity of drugs on the tissue. Some information will also be briefly presented about elastin, proteoglycans and glycoproteins in the dermis and in tissues other than skin.


Enzyme Replacement Therapy Collagen Synthesis Skin Fibroblast Human Skin Fibroblast Collagenase Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • B. Nusgens
  • C. M. Lapière

There are no affiliations available

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