Abstract
The development of topical non-steroidal anti-inflammatory drugs (NSAIDs), devoid of the unwanted effects of corticosteroids but with equal or even greater potency, has been an unattained ideal for many years. Considerable impetus was given to the search by the discovery by Vane (1971) that aspirin and other NSAIDs owed their effectiveness, at least in part, to their in vitro ability to suppress enzymatic transformation of arachidonic acid to its prostaglandin metabolites PGD2, PGI2 and PGE2 in a cell-free system, in concentrations which were of the same order of magnitude as those achieved therapeutically. This unique and specific inhibition occurs in almost all species and tissues examined. One useful by-product of Vane’s findings has been that NSAIDs can be used to explore the role of prostaglandins in a wide range of pathophysiological processes.
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Greaves, M.W., Shuster, S. (1989). Non-steroidal Anti-inflammatory Agents and the Skin. In: Greaves, M.W., Shuster, S. (eds) Pharmacology of the Skin II. Handbook of Experimental Pharmacology, vol 87 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74054-1_23
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DOI: https://doi.org/10.1007/978-3-642-74054-1_23
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